c-Abl in Neurodegenerative Disease
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The c-Abl tyrosine kinase participates in a variety of cellular functions, including regulation of the actin cytoskeleton, regulation of the cell cycle, and the apoptotic/cell cycle arrest response to stress, and the Abl family of kinases has been shown to play a crucial role in development of the central nervous system. Recent studies have shown c-Abl activation in human Alzheimer’s and Parkinson’s diseases and c-Abl activation in mouse models and neuronal culture in response to amyloid beta fibrils and oxidative stress. Overexpression of active c-Abl in adult mouse neurons results in neurodegeneration and neuroinflammation. Based on this evidence, a potential role for c-Abl in the pathogenesis of neurodegenerative disease is discussed, and we attempt to place activation of c-Abl in context with other known contributors to neurodegenerative pathology.
KeywordsTau Alzheimer’s c-Abl Tyrosine kinase Tauopathy
Supported by Applied Neurosolutions Inc and by NIMH38623 and AG022102. We thank Dr. Dennis Dickson for the human tauopathy cases used for experiments as shown in Fig. 2.