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Journal of Molecular Neuroscience

, Volume 45, Issue 3, pp 445–452 | Cite as

c-Abl in Neurodegenerative Disease

  • Sarah D. Schlatterer
  • Christopher M. Acker
  • Peter DaviesEmail author
Article

Abstract

The c-Abl tyrosine kinase participates in a variety of cellular functions, including regulation of the actin cytoskeleton, regulation of the cell cycle, and the apoptotic/cell cycle arrest response to stress, and the Abl family of kinases has been shown to play a crucial role in development of the central nervous system. Recent studies have shown c-Abl activation in human Alzheimer’s and Parkinson’s diseases and c-Abl activation in mouse models and neuronal culture in response to amyloid beta fibrils and oxidative stress. Overexpression of active c-Abl in adult mouse neurons results in neurodegeneration and neuroinflammation. Based on this evidence, a potential role for c-Abl in the pathogenesis of neurodegenerative disease is discussed, and we attempt to place activation of c-Abl in context with other known contributors to neurodegenerative pathology.

Keywords

Tau Alzheimer’s c-Abl Tyrosine kinase Tauopathy 

Notes

Acknowledgments

Supported by Applied Neurosolutions Inc and by NIMH38623 and AG022102. We thank Dr. Dennis Dickson for the human tauopathy cases used for experiments as shown in Fig. 2.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sarah D. Schlatterer
    • 1
  • Christopher M. Acker
    • 1
  • Peter Davies
    • 1
    • 2
    Email author
  1. 1.Department of PathologyAlbert Einstein College of MedicineBronxUSA
  2. 2.Litwin-Zucker Center for Research in Alzheimer’s Disease and Memory Disorders, Feinstein Center for Medical Research, North ShoreLong Island Jewish Health SystemManhassetUSA

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