Immunotherapy for Tauopathies
Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach. Studies pioneered by our laboratory and confirmed by others have shown that both active and passive immunizations targeting disease-related tau epitopes successfully reduce tau aggregates in vivo and slow or prevent behavioral impairments in mouse models of tauopathy. Here, we summarize recent advances in this new field.
KeywordsTau Tangles Immunization Immunotherapy Alzheimer's disease Tauopathies Mice
This study is supported by NIH grants AG032611, AG020197, the Alzheimer's Association, the Alzheimer's Drug Discovery Foundation/Association for Frontotemporal Dementia, and the Irma T Hirschl/Monique Caulier Trust.
Patent is pending on tau immunotherapy.
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