Journal of Molecular Neuroscience

, Volume 44, Issue 1, pp 1–5

Fyn Polymorphisms are Associated with Distinct Personality Traits in Healthy Chinese-Han Subjects

  • Jingying Li
  • Huan Ma
  • Shumin Deng
  • Lijuan Wu
  • Yinglin Huang
  • Gang Zhu


The Src family tyrosine kinase Fyn regulates a myriad of neurophysiological processes, including learning and memory. To date, the role of Fyn in the neurological mechanisms that determine personality traits has not been addressed. To this end, we determined the association between the rs706895C/T polymorphism of the Fyn gene (FYN) and personality traits measured by the Tridimensional Personality Questionnaire in 502 healthy Chinese-Han subjects. There were no significant differences in the total scores for novelty seeking (χ2 = 5.12, P = 0.077), harm avoidance (HA; χ2 = 2.63, P = 0.269), or reward dependence (RD; χ2 = 3.94, P = 0.139) among the rs706895C/T genotypes. In sub-item analyses, however, both fear of uncertainty (HA2; χ2 = 7.84, P = 0.020) and sentimentality (RD1; χ2 = 8.27; P = 0.016) scores were significantly different among rs706895C/T genotypes. Our results suggest that FYN alleles can contribute to the variance in human personality traits.


Fyn Polymorphism Personality Chinese 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jingying Li
    • 1
  • Huan Ma
    • 1
  • Shumin Deng
    • 2
  • Lijuan Wu
    • 1
  • Yinglin Huang
    • 1
  • Gang Zhu
    • 1
  1. 1.Department of PsychiatryThe First Affiliated Hospital of China Medical UniversityShenyangChina
  2. 2.Department of NeurologyThe First Affiliated Hospital of China Medical UniversityShenyangChina

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