Journal of Molecular Neuroscience

, Volume 36, Issue 1–3, pp 241–244 | Cite as

Maxadilan, the PAC1 Receptor, and Leishmaniasis

  • Vemuri B. Reddy
  • Yhong Li
  • Ethan A. LernerEmail author


Maxadilan is a vasodilator peptide isolated from sand fly salivary glands. The vasodilator effects of maxadilan are mediated by the PAC1 receptor, although maxadilan and PACAP do not share sequence homology. Sand flies are the vector of the parasitic disease leishmaniasis. The peptide aids the sand fly in obtaining a blood meal while enhancing the infectivity of leishmania parasites transmitted by this arthropod vector. Aspects of maxadilan, PAC1, and leishmaniasis are discussed.


Maxadilan Sand fly Leishmaniasis 


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Copyright information

© Humana Press 2008

Authors and Affiliations

  1. 1.Cutaneous Biology Research Center, Department of DermatologyMassachusetts General HospitalCharelestonUSA

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