Journal of Molecular Neuroscience

, Volume 34, Issue 2, pp 173–176

Association Between Alzheimer’s Disease and the NOS3 gene Glu298Asp Polymorphism in Chinese

  • Binbin Wang
  • Sainan Tan
  • Ze Yang
  • Yan-Chen Xie
  • Jing Wang
  • Sirui Zhou
  • Shu Li
  • Chenguang Zheng
  • Xu Ma
Article

Abstract

The oxidative stress caused by nitric oxide (NO) in the brain has been proposed as a pathogenic mechanism in Alzheimer’s disease. Endothelial NO synthase (ecNOS) produces the majority of circulating NO. The biological functional and genetic association studies suggested that the Glu298Asp polymorphism of the ecNOS gene (NOS3) may be a genetic risk factor for late-onset Alzheimer’s disease (LOAD). To investigate an association between the NOS31 Glu298Asp polymorphism and sporadic LOAD in Chinese, we examined 338 LOAD patients and 378 healthy controls. The associations of the Glu/Glu genotype and Glu allele with LOAD (χ2 = 9.12, df = 1, P = 0.003 by genotype; χ2 = 8.37, df = 1, P = 0.038 by allele) were found. After stratifying by apolipoprotein E allele 4 (APOE ɛ4) status, increased LOAD risks associated with the Glu/Glu genotype and Glu allele only in the APOE ɛ4 noncarriers (χ2 = 6.28, df = 1, P = 0.012 by genotype; χ2 = 5.62, df = 1, P = 0.018 by allele) were seen. These results suggest that the NOS3 gene Glu298Asp polymorphism might be a risk factor for LOAD and dependent on APOE ɛ4 status in Chinese.

Keywords

Late-onset Alzheimer’s disease Endothelial nitric oxide synthase NOS3 Apolipoprotein E Polymorphism Chinese 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Binbin Wang
    • 1
    • 4
  • Sainan Tan
    • 1
    • 4
  • Ze Yang
    • 2
  • Yan-Chen Xie
    • 3
  • Jing Wang
    • 1
    • 4
  • Sirui Zhou
    • 1
    • 4
  • Shu Li
    • 2
  • Chenguang Zheng
    • 5
  • Xu Ma
    • 1
    • 4
    • 6
  1. 1.Center for GeneticsNational Research Institute for Family PlanningBeijingChina
  2. 2.Laboratory for Medical Genetics, Institute of Geriatrics, Beijing HospitalMinistry of HealthBeijingChina
  3. 3.Department of Neurology, Beijing Friendship HospitalAffiliate of Capital University of Medical SciencesBeijingChina
  4. 4.Peking Union Medical CollegeBeijingChina
  5. 5.Jiangbin HospitalNanningChina
  6. 6.World Health Organization Collaborating Centre for Research in Human ReproductionBeijingChina

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