Extraluminal Duodenal Gangliocytic Paraganglioma Presenting with Intractable Back Pain in a Patient with End-Stage Renal Disease

  • Maxwell Kilcoyne
  • Gabrielle GauvinEmail author
  • Jennifer Cooley
  • Rajeswari Nagarathinam
  • Max Lefton
  • Alexander Kutikov
  • Sanjay Reddy
Case Report


Gangliocytic paragangliomas (GP) are rare neuroendocrine tumors (NET) defined by their triphasic histological features containing epithelioid, spindle, and ganglion-like cells [1]. While GPs are nonfunctional benign NETs with a favorable prognosis [2], preoperative diagnosis and surgical planning remain challenging as they are often misdiagnosed for other more aggressive NETs [3]. GPs are most commonly located in the 2nd portion of the duodenum, although there are reports of GPs found in the respiratory system, spinal cord, esophagus, pancreas, and appendix [1, 2]. GPs arising in the gastrointestinal tract are typically seen on endoscopy extending intraluminally. To our knowledge, this is the first case report of a large GP originating from the duodenum but completely invisible on endoscopy and extending into the retroperitoneum.

Case Description

A 57-year-old male with a history of hypertension and end stage renal disease (ESRD) on dialysis was admitted to the hospital...


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


Patient had been informed and gave their consent regarding this publication.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

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