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Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma

  • Jaffer Naqvi
  • Anna LeeEmail author
  • Ariel Lederman
  • Ami Kavi
  • Virginia W. Osborn
  • David Schreiber
Original Research
  • 5 Downloads

Abstract

Purpose

Anal mucosal melanoma is an uncommon malignancy of the anal canal, with few large studies available to establish clear trends in the treatment modalities presently available. The primary goal of this study was to identify the patterns of care in the treatment of anal melanoma and secondarily to determine outcomes.

Methods

This was a retrospective study performed utilizing the National Cancer Database (NCDB). A total of 787 patients diagnosed with anal melanoma between 2004 and 2014 were selected, of which 398 had staging information. The four treatment groups analyzed were surgical excision alone, surgical excision and radiation therapy, surgical excision and immunotherapy/chemotherapy, and radiation therapy plus minus immunotherapy/chemotherapy. Treatment was grouped by extent of disease; the Kaplan-Meier method was used to analyze overall survival and multivariate Cox proportional model was used to identify factors associated with overall survival.

Results

The majority of patients presented with either node-positive (39.4%) or metastatic disease (37.4%). Patients with surgical excision and radiation therapy had the highest median survival at 32.3 months. This is in contrast with those receiving surgical excision alone (22.9 months), surgery and immunotherapy/chemotherapy (18.4 months), and radiation without surgery (5.1 months) (p < 0.0001).

Conclusions

Treatment with surgical excision was the most common initial treatment with no single modality superior over another in this rare entity.

Keywords

Anal melanoma NCDB Mucosal 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Financial Disclosure

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Radiation OncologySUNY Downstate Medical CenterBrooklynUSA
  2. 2.Department of Veterans AffairsNew York Harbor Healthcare SystemBrooklynUSA
  3. 3.Department of Radiation OncologyElmhurst Hospital CenterQueensUSA
  4. 4.Summit Medical GroupBerkeley HeightsUSA

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