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The Incidence of Hepatocellular Carcinoma in Iran from 1996 to 2016: a Systematic Review and Meta-analysis

  • Soheil Hassanipour
  • Majid Mohammadzadeh
  • Fariborz Mansour-GhanaeiEmail author
  • Mohammad Fathalipour
  • Farahnaz Joukar
  • Hamid Salehiniya
  • Elham Abdzadeh
  • Ali Akbar Samadani
  • Hossein-Ali Nikbakht
  • Morteza Arab-Zozani
Review Article
  • 21 Downloads

Abstract

Purpose

Hepatocellular carcinoma or liver cancer (LC) is one of most important cancer around the world. There are several reports about LC incidence from various Iranian locations with conflicting results. The present study aimed to accomplish a systematic review to estimate the accurate incidence rate of LC among Iranian people.

Methods

This systematic review was performed based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist in 2018. A literature search was conducted using international databases (Medline/PubMed, Scopus, ScienceDirect, and Google Scholar) for English papers and national databases (Scientific Information Database, MagIran, IranMedex, and IranDoc) for Persian papers which estimated incidence rate of LC in any geographical area of Iran. The incidence rate of LC was calculated using random effect model.

Results

Of 171 papers in the primary searches, 15 studies were included by advanced screening and refinement. The age-standardized rate (ASR) of LC was 1.66 (95% CI 1.49–1.83) for males and 1.25 (95% CI 1.12–1.38) for females.

Conclusions

The incidence rate of LC in Iran was lower in comparison to other countries. Afterwards, more studies are necessary to outline the accurate incidence rate and the trend of LC among Iranian population.

Keywords

Incidence Hepatocellular carcinoma Iran Systematic review Meta-analysis 

Notes

Funding Information

This study was financially provided by Guilan University of Medical Sciences, Rasht, Iran.

Compliance with Ethical Standards

This study was conducted in compliance with the provisions of the Helsinki Declaration. The protocol was approved by the ethics committee of Guilan University of Medical Sciences.

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30.  https://doi.org/10.3322/caac.21332.Google Scholar
  2. 2.
    Zhu RX, Seto WK, Lai CL, Yuen MF. Epidemiology of hepatocellular carcinoma in the Asia-Pacific region. Gut and liver. 2016;10(3):332–9.  https://doi.org/10.5009/gnl15257.Google Scholar
  3. 3.
    Torre LA, Sauer AM, Chen MS Jr, Kagawa-Singer M, Jemal A, Siegel RL. Cancer statistics for Asian Americans, Native Hawaiians, and Pacific Islanders, 2016: converging incidence in males and females. CA Cancer J Clin. 2016;66(3):182–202.  https://doi.org/10.3322/caac.21335.Google Scholar
  4. 4.
    McGlynn KA, Petrick JL, London WT. Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability. Clin Liver Dis. 2015;19(2):223–38.  https://doi.org/10.1016/j.cld.2015.01.001.Google Scholar
  5. 5.
    da Motta Girardi D, Correa TS, Crosara Teixeira M, Dos Santos Fernandes G. Hepatocellular carcinoma: review of targeted and immune therapies. J Gastrointest Cancer. 2018;49(3):227–36.  https://doi.org/10.1007/s12029-018-0121-4.Google Scholar
  6. 6.
    La Vecchia C, Lucchini F, Franceschi S, Negri E, Levi F. Trends in mortality from primary liver cancer in Europe. Eur J Cancer. 2000;36(7):909–15.Google Scholar
  7. 7.
    Levi F, La Vecchia C, Lucchini F, Negri E. Worldwide trends in cancer mortality in the elderly, 1955-1992. Eur J Cancer. 1996;32A(4):652–72.Google Scholar
  8. 8.
    El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012;142(6):1264–73 e1261.  https://doi.org/10.1053/j.gastro.2011.12.061.Google Scholar
  9. 9.
    Seeff LB, Hoofnagle JH. Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene. 2006;25(27):3771–7.  https://doi.org/10.1038/sj.onc.1209560.Google Scholar
  10. 10.
    Tu T, Buhler S, Bartenschlager R. Chronic viral hepatitis and its association with liver cancer. Biol Chem. 2017;398(8):817–37.  https://doi.org/10.1515/hsz-2017-0118.Google Scholar
  11. 11.
    Ringelhan M, McKeating JA, Protzer U. Viral hepatitis and liver cancer. Philos Trans R Soc Lond Ser B Biol Sci. 2017;372(1732):20160274.  https://doi.org/10.1098/rstb.2016.0274.Google Scholar
  12. 12.
    Joukar F, Mansour-Ghanaei F, Naghipour MR, Hassanipour S. Knowledge, distribution and risk factors of hepatitis B and C infection in High-risk Groups in Guilan Province, Iran. Hepat Mon. 2018;18(8):e65870.Google Scholar
  13. 13.
    Chen ZM, Liu BQ, Boreham J, Wu YP, Chen JS, Peto R. Smoking and liver cancer in China: case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths. Int J Cancer. 2003;107(1):106–12.  https://doi.org/10.1002/ijc.11342.Google Scholar
  14. 14.
    Corrao G, Bagnardi V, Zambon A, La Vecchia C. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med. 2004;38(5):613–9.  https://doi.org/10.1016/j.ypmed.2003.11.027.Google Scholar
  15. 15.
    Vanni E, Bugianesi E. Obesity and liver cancer. Clin Liver Dis. 2014;18(1):191–203.  https://doi.org/10.1016/j.cld.2013.09.001.Google Scholar
  16. 16.
    Fernandez E, La Vecchia C, D'Avanzo B, Negri E, Franceschi S. Family history and the risk of liver, gallbladder, and pancreatic cancer. Cancer Epidemiol Biomarkers Prevent : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1994;3(3):209–12.Google Scholar
  17. 17.
    Turati F, Edefonti V, Talamini R, Ferraroni M, Malvezzi M, Bravi F, et al. Family history of liver cancer and hepatocellular carcinoma. Hepatology. 2012;55(5):1416–25.  https://doi.org/10.1002/hep.24794.Google Scholar
  18. 18.
    Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver Cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317(5834):121–4.  https://doi.org/10.1126/science.1140485.Google Scholar
  19. 19.
    Saadat S, Yousefifard M, Asady H, Jafari AM, Fayaz M, Hosseini M. The most important causes of death in Iranian population; a retrospective cohort study. Emergency. 2015;3(1):16–21.Google Scholar
  20. 20.
    Azizi MH, Bahadori M, Azizi F. History of cancer in Iran. Arch Iran Med. 2013;16(10):613–22.Google Scholar
  21. 21.
    Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z. Cancer incidence and mortality in Iran. Ann Oncol : official journal of the European Society for Medical Oncology. 2009;20(3):556–63.  https://doi.org/10.1093/annonc/mdn642.Google Scholar
  22. 22.
    Mirzaei M, Ghoncheh M, Pournamdar Z, Soheilipour F, Salehiniya H. Incidence and trend of liver cancer in Iran. J Coll Physicians Surg Pak: JCPSP. 2016;26(4):306–9.Google Scholar
  23. 23.
    Nikbakht HA, Sahraian S, Ghaem H, Javadi A, Janfada M, Hassanipour S, et al. Trends in mortality rates for gastrointestinal cancers in Fars province, Iran (2005–2015). J Gastrointest Cancer. 2019:1-7.  https://doi.org/10.1007/s12029-019-00204-1.
  24. 24.
    Deshpande S, van Asselt A, Tomini F, Armstrong N, Allen A, Noake C, et al. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. 2013.Google Scholar
  25. 25.
    Institute JB. The Joanna Briggs Institute Critical Appraisal tools for use in JBI systematic reviews checklist for analytical cross sectional studies. In: The Joanna Briggs institute. Australia: North Adelaide; 2017.Google Scholar
  26. 26.
    Harris RJ, Bradburn MJ, Deeks JJ, Harbord RM, Altman DG, Sterne JAC. Metan: fixed- and random-effects meta-analysis. Stata J. 2008;8(1):3–28.Google Scholar
  27. 27.
    Bagos PG, Nikolopoulos GK. Mixed-effects poisson regression models for meta-analysis of follow-up studies with constant or varying durations. Int J Biostat. 2009;5(1):1557–79.Google Scholar
  28. 28.
    Mehrabani D, Tabei SZ, Heydari ST, Shamsina SJ, Shokrpour N, Amini M, et al. Cancer occurrence in Fars province, southern Iran. Iran Red Crescent Me. 2008;10(4):314–22.Google Scholar
  29. 29.
    Masoompour SM, Yarmohammadi H, Rezaianzadeh A, Lankarani KB. Cancer incidence in southern Iran, 1998-2002: results of population-based cancer registry. Cancer Epidemiol. 2011;35(5):e42–7.  https://doi.org/10.1016/j.canep.2011.05.018.Google Scholar
  30. 30.
    Masoompour SM, Lankarani KB, Honarvar B, Tabatabaee SH, Moghadami M, Khosravizadegan Z. Changing epidemiology of common cancers in southern Iran, 2007-2010: a cross sectional study. PLoS One. 2016;11(5):e0155669.  https://doi.org/10.1371/journal.pone.0155669.Google Scholar
  31. 31.
    Sadjadi A, Malekzadeh R, Derakhshan MH, Sepehr A, Nouraie M, Sotoudeh M, et al. Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran. Int J Cancer. 2003;107(1):113–8.  https://doi.org/10.1002/ijc.11359.Google Scholar
  32. 32.
    Babaei M, Jaafarzadeh H, Sadjadi AR, Samadi F, Yazdanbod A, Fallah M, et al. Cancer incidence and mortality in Ardabil: report of an ongoing population-based cancer registry in Iran, 2004-2006. Iran J Public Health. 2009;38(4):35–45.Google Scholar
  33. 33.
    Sadiadi A, Zahedi MJ, Moghadam SD, Nouraie M, Alimohammadian M, Ghorbani A, et al. The first population-based cancer survey in Kerman Province of Iran. Iran J Public Health. 2007;36(4):26–34.Google Scholar
  34. 34.
    Babai M, Mousavi S, Malek M, Danaie N, Jandaghi J, Tousi J, et al. Survey of cancer incidence during a 5-year (1998-2002) period in Semnan province. Koomesh. 2005;6(3):237–44.Google Scholar
  35. 35.
    Somi MH, Farhang S, Mirinezhad SK, Naghashi S, Seif-Farshad M, Golzari M. Cancer in East Azerbaijan, Iran: results of a population-based cancer registry. Asian Pac J Cancer Prev. 2008;9(2):327–30.Google Scholar
  36. 36.
    Mohagheghi MA, Mosavi-Jarrahi A, Malekzadeh R, Parkin M. Cancer incidence in Tehran metropolis: the first report from the Tehran Population-based Cancer Registry, 1998-2001. Arch Iran Med. 2009;12(1):15–23.Google Scholar
  37. 37.
    Fateh M, Emamian MH. Cancer incidence and trend analysis in Shahroud, Iran, 2000 - 2010. Iran J Cancer Prev. 2013;6(2):85–94.Google Scholar
  38. 38.
    Basiri A, Shakhssalim N, Jalaly NY, Miri HH, Partovipour E, Panahi MH. Difference in the incidences of the most prevalent urologic cancers from 2003 to 2009 in Iran. Asian Pac J Cancer Prev. 2014;15(3):1459–63.  https://doi.org/10.7314/Apjcp.2014.15.3.1459.Google Scholar
  39. 39.
    Roshandel G, Boreiri M, Sadjadi A, Malekzadeh R. A diversity of cancer incidence and mortality in West Asian populations. Annals of global health. 2014;80(5):346–57.  https://doi.org/10.1016/j.aogh.2014.09.012.Google Scholar
  40. 40.
    Mirzaei M, Pournamdar Z, Salehiniya H. Epidemiology and trends in incidence of kidney cancer in Iran. Asian Pac J Cancer Prev. 2015;16(14):5859–61.  https://doi.org/10.7314/APJCP.2015.16.14.5859.Google Scholar
  41. 41.
    Arabsalmani M, Mohammadian-Hafshejani A, Ghoncheh M, Hadadian F, Towhidi F, Vafaee K, et al. Incidence and mortality of kidney cancers, and human development index in Asia; a matter of concern. J Nephropathol. 2017;6(1):30–42.  https://doi.org/10.15171/jnp.2017.06.Google Scholar
  42. 42.
    van Enst WA, Ochodo E, Scholten RJ, Hooft L, Leeflang MM. Investigation of publication bias in meta-analyses of diagnostic test accuracy: a meta-epidemiological study. BMC Med Res Methodol. 2014;14:70–4.  https://doi.org/10.1186/1471-2288-14-70.Google Scholar
  43. 43.
    Hassanipour S, Namvar G, Fathalipour M, Salehiniya H. The incidence of kidney cancer in Iran: a systematic review and meta-analysis. BioMedicine. 2018;8(2):9.  https://doi.org/10.1051/bmdcn/2018080209.Google Scholar
  44. 44.
    Hassanipour S, Mokhtari A, Fathalipour M, Salehiniya H. The Incidence of Lung Cancer in Iran: A Systematic Review and Meta-Analysis. World Cancer Research Journal. 2017;4(4):e980.Google Scholar
  45. 45.
    Azgomi S, Rezaianzadeh A, Mokhtari A, Maghsoudi A, Nazarzadeh M, Dehghani S, et al. The incidence of breast cancer in Iran: a systematic review and meta-analysis. J Anal Oncol. 2016;5(4):139–45.  https://doi.org/10.6000/1927-7229.2016.05.04.2.Google Scholar
  46. 46.
    Rezaianzadeh A, Jalali M, Maghsoudi A, Mokhtari AM, Azgomi SH, Dehghani SL. The overall 5-year survival rate of breast cancer among Iranian women: a systematic review and meta-analysis of published studies. Breast Dis (Preprint). 2017;37(2):63–8 1–6.Google Scholar
  47. 47.
    Rezaianzadeh A, Mokhtari AM, Hassanipour S, Maghsoudi A, Dehghani SL, Nazarzadeh M, et al. The age-standardized incidence rate of ovarian cancer in Iranian women: a systematic review and meta-analysis. Middle East J Cancer. 2018;9(3):171–8.Google Scholar
  48. 48.
    Mokhtari AM, Riahi S, Fathalipour M, Delam H, Hashemnejad M, Hassanipour S. The age-standardized rate of female genital cancers in Iran: a systematic review and meta-analysis. Tums-Hayat. 2018;24(3):204–19.Google Scholar
  49. 49.
    Hassanipour S, Ghorbani M, Derakhshan M, Fouladseresht H, Mohseni S, Abdzadeh E, et al. The incidence of testicular cancer in Iran from 1996 to 2017: a systematic review and meta-analysis. Adv Human Biol. 2019a;9(1):16.Google Scholar
  50. 50.
    Hassanipour S, Namvar G, Fathalipour M, Ghorbani M, Abdzadeh E, Zafarshamspour S, et al. The incidence of brain tumours in Iran: a systematic review and meta-analysis. Adv Human Biol. 2019b;9(1):2.Google Scholar
  51. 51.
    Mohammadian M, Soroush A, Mohammadian-Hafshejani A, Towhidi F, Hadadian F, Salehiniya H. Incidence and mortality of liver cancer and their relationship with development in Asia. Asian Pac J Cancer Prev. 2016;17(4):2041–7.Google Scholar
  52. 52.
    Arabsalmani M, Mirzaei M, Ghoncheh M, Soroush A, Towhidi F, Salehiniya H. Incidence and mortality of liver cancer and their relationship with the human development index in the world. Biomed Res Ther. 2016;3(9):800–7.  https://doi.org/10.7603/s40730-016-0041-5.Google Scholar
  53. 53.
    Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.  https://doi.org/10.1002/ijc.25516.Google Scholar
  54. 54.
    Khodabandehloo M, Roshani D, Sayehmiri K. Prevalence and trend of hepatitis C virus infection among blood donors in Iran: a systematic review and meta-analysis. J Res Med Sci. 2013;18(8):674–82.Google Scholar
  55. 55.
    Alavian SM, Hajarizadeh B, Ahmadzad-Asl M, Kabir A, Bagheri-Lankarani K. Hepatitis B virus infection in Iran: a systematic review. Hepat Mon. 2008;8(4):281–94.Google Scholar
  56. 56.
    Aghamohamad A, Montazeri M, Akbari M. Prevalence of hepatitis B and hepatitis C in blood donors at Semnan province from 2008 to 2011. Koomesh. 2014;15(2):162–7.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Soheil Hassanipour
    • 1
  • Majid Mohammadzadeh
    • 2
  • Fariborz Mansour-Ghanaei
    • 1
    Email author
  • Mohammad Fathalipour
    • 3
  • Farahnaz Joukar
    • 1
  • Hamid Salehiniya
    • 4
    • 5
  • Elham Abdzadeh
    • 6
  • Ali Akbar Samadani
    • 1
  • Hossein-Ali Nikbakht
    • 7
  • Morteza Arab-Zozani
    • 8
  1. 1.Gastrointestinal and Liver Diseases Research CenterGuilan University of Medical SciencesRashtIran
  2. 2.Student Research CommitteeShiraz University of Medical SciencesShirazIran
  3. 3.Department of Pharmacology and Toxicology, Faculty of PharmacyHormozgan University of Medical SciencesBandar AbbasIran
  4. 4.Zabol University of Medical SciencesZabolIran
  5. 5.Department of Epidemiology and BiostatisticsTehran University of medical sciencesTehranIran
  6. 6.Department of Biology, Faculty of ScienceUniversity of GuilanRashtIran
  7. 7.Social Determinants of Health Research Center, Health Research InstituteBabol University of Medical SciencesBabolIran
  8. 8.Iranian Center of Excellence in Health Management, School of Management and Medical InformaticsTabriz University of Medical SciencesTabrizIran

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