Journal of Gastrointestinal Cancer

, Volume 50, Issue 4, pp 967–971 | Cite as

“Pure” High-Grade Large Cell Neuroendocrine Carcinoma Arising from Low- and High-Grade Dysplasia of the Gallbladder: Case Report and Review of the Literature

  • Cacey Peters
  • Eleanor Lewin
  • Tong Wu
  • Yukihiro NakanishiEmail author
Case Report


Neuroendocrine neoplasms of the gallbladder are classified as grades 1 and 2 neuroendocrine tumors, neuroendocrine carcinoma (NEC) (large cell (LCNEC) or small cell type (SCNEC)), and mixed adenoneuroendocrine carcinoma (MANEC) [1]. NEC of the gallbladder is rare, comprising 0.5% of all neuroendocrine tumors and 2.1% of all gallbladder cancers [2]. In most cases of NEC of the gallbladder, the histological components include adenocarcinoma [3, 4, 5]. Among the reported cases of NEC of the gallbladder, only seven reported cases were “pure” LCNEC without adenocarcinoma component [3, 6, 7, 8, 9, 10]. The origin of such tumors has been debated, with varying support for each theory. The primary concepts consist of the malignant transformation of neuroendocrine cells derived from multipotent stem cell within the gallbladder or the malignant transformation of neuroendocrine cells in metaplastic intestinal or gastric mucosa secondary to chronic inflammation [3, 5].

We here report,...


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Conflict of Interests

The authors have no conflict of interests.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Cacey Peters
    • 1
  • Eleanor Lewin
    • 1
  • Tong Wu
    • 1
  • Yukihiro Nakanishi
    • 1
    Email author
  1. 1.Department of PathologyTulane University School of MedicineNew OrleansUSA

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