Journal of Gastrointestinal Cancer

, Volume 44, Issue 1, pp 115–117

Pregnancy with Metastatic Gastrointestinal Stromal Tumor (GIST) on Imatinib Chemotherapy: an Oncologist’s Nightmare and Obstetrician’s Dilemma

  • Neerja Goel
  • Ria Malik
  • Balkesh Rathi
  • Sruthi Bhaskaran
  • Shalini Rajaram
  • Sumita Mehta
  • Nitin Agarwal
Brief Communication



Gastrointestinal stromal tumors (GISTs) are among the few cancers amenable to successful treatment by targeted molecular therapy with KIT receptor inhibitors like imatinib mesylate. Increasing incidence of this tumor and its successful treatment has given rise to issues of fertility and child bearing in patients affected at young age. Although contraception advice and termination of early pregnancy have been the standard practice in patients on such therapy, an occasional patient who desires pregnancy can leave both obstetrician and oncologist perplexed.

Clinical Presentation

We report our experience in a rare patient of metastatic GIST who had a successful normal pregnancy while on imatinib therapy. We further attempt to evaluate similar evidence in literature.


Metastatic gastrointestinal stromal tumor Pregnancy Imatinib Cancer chemotherapy 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Neerja Goel
    • 1
  • Ria Malik
    • 1
  • Balkesh Rathi
    • 1
  • Sruthi Bhaskaran
    • 1
  • Shalini Rajaram
    • 1
  • Sumita Mehta
    • 1
  • Nitin Agarwal
    • 2
  1. 1.Department of Obstetrics and GynecologyUniversity College of Medical Sciences and Guru Teg Bahadur HospitalDelhiIndia
  2. 2.Department of SurgeryUniversity College of Medical Sciences and Guru Teg Bahadur HospitalDelhiIndia

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