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Journal of Gastrointestinal Cancer

, Volume 43, Supplement 1, pp 171–174 | Cite as

Concomitant Nonfunctional Pancreatic Neuroendocrine Tumor and Gastric GIST in a Patient Without Neurofibromatosis Type 1

  • Sven-Petter HaugvikEmail author
  • Bård Ingvald Røsok
  • Bjørn Edwin
  • Ivar Prydz Gladhaug
  • Øystein Mathisen
Case Report

Introduction

Neuroendocrine tumors are rare neoplasms, stemming from the diffuse endocrine system and with potential of development in almost every organ, including the pancreas [17]. Pancreatic neuroendocrine tumors (pNET) are associated with different genetic abnormalities in regulatory pathways of the cell cycle [5, 9, 10, 15, 19].

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract [20] and originate from the interstitial cell of Cajal [11]. They represent a heterogenous group of neoplasms, which is characterized by genetic alterations in the oncogenes KIT and PDGFRA [7, 8]. These oncogenes are used as molecular targets of selective tyrosine kinase inhibitors (e.g. imatinib) in the medical treatment of GIST [4]. GIST show a realtively high incidence in patients with neurofibromatosis type 1 (NF-1) [21], which is the most frequent inherited disease in the Western world [22].

There are, to the best of our knowledge, only three...

Keywords

Imatinib Octreotide Pancreatic Tail Pancreatic Neuroendocrine Tumor Gastric Gist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CT

Computed tomography

GIST

Gastrointestinal stromal tumor

NF-1

Neurofibromatosis type 1

pNET

Pancreatic neuroendocrine tumor

Notes

Acknowledgements

We would like to thank Prof. Sverre Heim, M.D., Ph.D., for analysing the cytogenetic data, Prof. Tor Jacob Eide, M.D., Ph.D., for performing the histopathology of the pNET and Dr. Jan Gunnar Fjeld, M.D., for analysing the data from the indium-111-labelled octreotide scintigraphy.

Competing Interests

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sven-Petter Haugvik
    • 1
    Email author
  • Bård Ingvald Røsok
    • 1
  • Bjørn Edwin
    • 1
    • 2
  • Ivar Prydz Gladhaug
    • 1
    • 3
  • Øystein Mathisen
    • 1
  1. 1.Department of Gastrointestinal SurgeryOslo University Hospital, RikshospitaletOsloNorway
  2. 2.Interventional Centre, Oslo University Hospital, RikshospitaletOsloNorway
  3. 3.Institute of Clinical MedicineUniversity of OsloOsloNorway

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