Concomitant Nonfunctional Pancreatic Neuroendocrine Tumor and Gastric GIST in a Patient Without Neurofibromatosis Type 1
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Neuroendocrine tumors are rare neoplasms, stemming from the diffuse endocrine system and with potential of development in almost every organ, including the pancreas . Pancreatic neuroendocrine tumors (pNET) are associated with different genetic abnormalities in regulatory pathways of the cell cycle [5, 9, 10, 15, 19].
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract  and originate from the interstitial cell of Cajal . They represent a heterogenous group of neoplasms, which is characterized by genetic alterations in the oncogenes KIT and PDGFRA [7, 8]. These oncogenes are used as molecular targets of selective tyrosine kinase inhibitors (e.g. imatinib) in the medical treatment of GIST . GIST show a realtively high incidence in patients with neurofibromatosis type 1 (NF-1) , which is the most frequent inherited disease in the Western world .
KeywordsImatinib Octreotide Pancreatic Tail Pancreatic Neuroendocrine Tumor Gastric Gist
Gastrointestinal stromal tumor
Neurofibromatosis type 1
Pancreatic neuroendocrine tumor
We would like to thank Prof. Sverre Heim, M.D., Ph.D., for analysing the cytogenetic data, Prof. Tor Jacob Eide, M.D., Ph.D., for performing the histopathology of the pNET and Dr. Jan Gunnar Fjeld, M.D., for analysing the data from the indium-111-labelled octreotide scintigraphy.
The authors declare no conflict of interest.
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