Journal of Gastrointestinal Cancer

, Volume 42, Issue 3, pp 123–126

Disseminated Carcinoma Diagnosed by Bone Marrow Biopsy in Patients with Microangiopathic Hemolytic Anemia and Thrombocytopenia: A Report of Two Cases with Gastric Cancer and a Review of the Literature

  • Orit Kaidar-Person
  • Haitam Nasrallah
  • Nissim Haim
  • Eldad J. Dann
  • Gil Bar-Sela
Review Article

DOI: 10.1007/s12029-010-9204-6

Cite this article as:
Kaidar-Person, O., Nasrallah, H., Haim, N. et al. J Gastrointest Canc (2011) 42: 123. doi:10.1007/s12029-010-9204-6

Abstract

Introduction

Malignancy is often associated with hematological disorders, but rarely is the diagnosis of malignancy secondary to the diagnosis of microangiopathic hemolytic anemia and thrombocytopenia.

Case reports

We report hereby two patients with metastatic gastric carcinoma presenting with microangiopathic hemolytic anemia and thrombocytopenia. Despite chemotherapy and repeated plasmapheresis in one patient, both patients succumbed shortly after the diagnosis of cancer was made.

Conclusion

A review of the literature regarding microangiopathic hemolytic anemia in cancer patients is discussed. In patients suffering from microangiopathic hemolytic anemia and thrombocytopenia, malignancy should be considered as a possible cause. Early diagnosis of malignancy may be critical for determining the patient’s prognosis and potentially avoiding unnecessary overtreatment.

Keywords

Microangiopathic hemolytic anemia Thrombocytopenia TTP HUS Gastric Adenocarcinoma 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Orit Kaidar-Person
    • 1
  • Haitam Nasrallah
    • 1
  • Nissim Haim
    • 1
  • Eldad J. Dann
    • 2
  • Gil Bar-Sela
    • 1
  1. 1.Division of Oncology, Rambam Health Care Campus and Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael
  2. 2.Department of Hematology, Rambam Health Care Campus and Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael

Personalised recommendations