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Journal of Gastrointestinal Cancer

, Volume 42, Issue 4, pp 296–301 | Cite as

Gastric Metastasis in Renal Cell Carcinoma: A Case Report and Systematic Review

  • Guy D. EslickEmail author
  • Jamshid S. Kalantar
Brief Communication

Abstract

Background

Published report of cases of gastric metastases arising from renal cell carcinoma is a rare event and treatment of such patients can be difficult. Gastrectomy may be a surgical alternative; however, the prognosis for the majority of patients is very poor.

Methods

We report a rare case of a patient with a metastatic renal cell carcinoma that metastasized to the stomach. In addition, we conducted a systematic review of the literature to assess the prevalence of reports and to gain a greater understanding of this particular metastatic cancer spread from the kidney to the stomach.

Results

Published reports of metastases from the kidney to the stomach are not as rare as previously thought with three times of the number of reports found to what most authors thought actually existed. The majority of reports occurred among males (77%). The mean age of presentation was 65 years for males and 68 years for females (range, 40–84 years). Average time from nephrectomy to presentation of gastric metastases was 7 years for both males and females (range, 0–24 years).

Conclusion

Females with gastric metastases from the kidney are slightly older than males, and no difference exists between males and females in terms of the time interval between nephrectomy and subsequent metastasis or select patients treatment options.

Keywords

gastric cancer metastasis renal cell carcinoma clear cell carcinoma systematic review 

Notes

Acknowledgments

We would like to thank Futoshi Kitajima for the translation of the Japanese paper which allowed us to include additional 15 cases in our review.

Conflict of Interest

None

Source of Funding

None

References

  1. 1.
    Kobayashi O, Murakami H, Yoshida T, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World J Surg. 2004;28:548–51.PubMedCrossRefGoogle Scholar
  2. 2.
    Portanova M, Yabar A, Lombardi E, et al. Concomitant gastric and pancreatic metastases from renal cell carcinoma: case study. Rev Gastroenterol Perú. 2006;26:84–8.PubMedGoogle Scholar
  3. 3.
    Mascarenhas B, Konetty B, Rubin JT. Recurrent metastatic renal cell carcinoma presenting as a bleeding gastric ulcer after a complete response to high-dose interleukin-2 treatment. Urology. 2001;57:168x–168xiii.CrossRefGoogle Scholar
  4. 4.
    Greendyke WH, Resnick DL, Schellhammer PF. Clear cell carcinoma of the kidney simulating an intramural gastric tumour. Clin Radiol. 1971;22:222–4.PubMedCrossRefGoogle Scholar
  5. 5.
    Uemura T, Kurita A, Nishimura R, et al. Solitary pancreatic metastasis from renal cell carcinoma concomitant with early gastric cancer 17 years after nephrectomy: report of a case. Surg Today. 2003;33:395–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Graadt van Roggen JF, van Velthuysen ML, Hogendoorn PC. The histopathological differential diagnosis of gastrointestinal stromal tumours. J Clin Pathol. 2001;54:96–102.PubMedCrossRefGoogle Scholar
  7. 7.
    Corless CL, Fletcher JA, Heinrich MC. Biology of gastrointestinal stromal tumors. J Clin Oncol. 2004;22:3813–25.PubMedCrossRefGoogle Scholar
  8. 8.
    Nowain A, Bhakta H, Pais S, et al. Gastrointestinal stromal tumors: clinical profile, pathogenesis, treatment strategies and prognosis. J Gastroenterol Hepatol. 2005;20:818–24.PubMedCrossRefGoogle Scholar
  9. 9.
    Picchio M, Paioletti A, Santini E, et al. Gastric metastasis from renal cell carcinoma fourteen years after radical nephrectomy. Acta Chir Belg. 2000;100:228–30.PubMedGoogle Scholar
  10. 10.
    Suarez FC, Carballido RJ, Gonzalez LY, et al. Gastric metastasis from renal cell carcinoma. Pathological hypothesis and literature revision. Actas Urol Esp. 2004;28:472–6.Google Scholar
  11. 11.
    Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 2006;295:2516–24.PubMedCrossRefGoogle Scholar
  12. 12.
    Matsuzaki T, Yashiro M, Kaizaki R, Yasuda K, Doi Y, Sawada T, et al. Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer. Cancer Sci. 2009;100:2402–10.PubMedCrossRefGoogle Scholar
  13. 13.
    Vecchione L, Orditura M, Ciardiello F, De Vita F. Novel investigational drugs for gastric cancer. Expert Opin Investig Drugs. 2009;18:945–55.PubMedCrossRefGoogle Scholar
  14. 14.
    Arkenau HT. Gastric cancer in the era of molecularly targeted agents: current drug development strategies. J Cancer Res Clin Oncol. 2009;135:855–66.PubMedCrossRefGoogle Scholar
  15. 15.
    Ohtsu A. Chemotherapy for metastatic gastric cancer: past, present, and future. J Gastroenterol. 2008;43:256–64.PubMedCrossRefGoogle Scholar
  16. 16.
    Maeda T, Kozakai N, Nishiyama T, Ishii T, Sugiura H, Nakamura K. Gastric metastasis from renal cell carcinoma 20 months after radical nephrectomy: a case report. Hinyokika Kiyo–Acta Urologica Japonica. 2009;55:137–40.PubMedGoogle Scholar
  17. 17.
    Saidi RF, Remine SG. Isolated gastric metastasis from renal cell carcinoma 10 years after radical nephrectomy. J Gastroenterol Hepatol. 2007;22:143–4.PubMedCrossRefGoogle Scholar
  18. 18.
    Durous E, Isaac S, Dubreuil C, Braillon G, Bonvoisin S, Descos L. Late gastric metastasis of cancer of the kidney. Presse Méd. 1992;21:996.PubMedGoogle Scholar
  19. 19.
    Mayeur D, David B, Boidart F, Dubrujeaud J. Gastric metastasis of cancer of the kidney. Gastroentérol Clin Biol. 1993;17:309–10.PubMedGoogle Scholar
  20. 20.
    Sullivan WG, Cabot EB, Donohue RE. Metastatic renal cell carcinoma to stomach. Urology. 1980;15:375–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Odori T, Tsuboi Y, Katoh K, et al. A solitary hematogenous metastasis to the gastric wall from renal cell carcinoma four years after radical nephrectomy. J Clin Gatroenterol. 1998;26:153–4.CrossRefGoogle Scholar
  22. 22.
    Marquez JL, Herrera JM, Herrera J, et al. Gastric metastasis of renal cell adenocarcinoma. Rev Esp Enferm Dig. 1992;81:129–30.PubMedGoogle Scholar
  23. 23.
    Ibanez Olcoz J, Jimenez Lopez CE, Oteo Revuelta JA, et al. Gastric metastasis of renal adenocarcinoma. Presentation of a case and review of the literature. Rev Esp Enferm Apar Dig. 1989;76:259–61.PubMedGoogle Scholar
  24. 24.
    Cosme A, Orive V, Alzate LF, Torrado J, Arenal JI. Metástasis gástrica de un hipernefroma. Gastroenterol Hepatol. 1984;7:400–1.Google Scholar
  25. 25.
    Bisesti V, Parrella E, Cataldi C, Rizzo R, Onufrio A. Ser di un raro caso di metastasi gastrica di adenocarcinoma renale. Osp Ital Pediatr. 1984;19:609–20.Google Scholar
  26. 26.
    Suárez Fonseca C, Carballido Rodríguez J, González Lama Y, Sola Galarza I, Rodríguez Reina G, Salas Antón C. Gastric metastasis from renal cell carcinoma. Pathogenical hypothesis and literature revision. Actas Urol Esp. 2004;28:472–6.PubMedGoogle Scholar
  27. 27.
    Pezzoli A, Matarese V, Boccia S, Simone L, Gullini S. Gastrointestinal bleeding from gastric metastasis of renal cell carcinoma, treated by endoscopic polypectomy. Endoscopy. 2007;39:E52.PubMedCrossRefGoogle Scholar
  28. 28.
    Garcia-Campelo R, Quindos M, Vazquez DD, Lopez MR, Carral A, Calvo OF, et al. Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma. Anticancer Drugs. 2010;21 Suppl 1:S13–5.PubMedCrossRefGoogle Scholar
  29. 29.
    Riviello C, Ilaria T, Cipriani G, et al. Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature. World J Gastroenterol. 2006;12:5234–6.PubMedGoogle Scholar
  30. 30.
    Herrera Puerto J, Caballero Gomez M, Marquez Galan JL, et al. Metastatic hypernephroma of the stomach. Arch Esp Urol. 1993;46:729–31.PubMedGoogle Scholar
  31. 31.
    Boruchowicz A, Desreumaux P, Maunoury V, Colombel JF. Dysphagia revealing esophageal and gastric metastases of renal carcinoma. Am J Gastroenterol. 1995;90:2263–4.PubMedGoogle Scholar
  32. 32.
    Blake MA, Owens A, O'Donoghue DP, MacErlean DP. Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995;37:835–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Kok Wee L, Shyu RY, Sheu LF, Hsieh TY, Yan JC, Chen PJ. Metastatic renal cell cancer. Gastrointest Endosc. 2004;60:265.PubMedCrossRefGoogle Scholar
  34. 34.
    Lamb GW, Moss J, Edwards R, Aitchison M. Octreotide as an adjunct to embolisation in the management of recurrent bleeding upper gastrointestinal metastases from primary renal cell cancer. Int Urol Nephrol. 2005;37:691–3.PubMedCrossRefGoogle Scholar
  35. 35.
    Pollheimer MJ, Hinterleitner TA, Pollheimer VS, Schlemmer A, Langner C. Renal cell carcinoma metastatic to the stomach: single-centre experience and literature review. BJU Int. 2008;102:315–9.PubMedCrossRefGoogle Scholar
  36. 36.
    Kibria R, Sharma K, Syed AA, Rao P. Upper gastrointestinal bleeding revealing the stomach metastases of renal cell carcinoma. J Gastrointest Cancer. 2009;40:51–4.PubMedCrossRefGoogle Scholar
  37. 37.
    Yamamoto D, Hamada Y, Okazaki S, Kawakami K, Kanzaki S, Yamamoto C, et al. Metastatic gastric tumor from renal cell carcinoma. Gastric Cancer. 2009;12:170–3.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.The Whiteley-Martin Research Centre Discipline of Surgery, The University of SydneySydney Medical School, NepeanPenrithAustralia
  2. 2.Department of GastroenterologyNepean HospitalPenrithAustralia
  3. 3.Department of Medicine, The University of SydneyNepean HospitalPenrithAustralia

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