Advertisement

Journal of Gastrointestinal Cancer

, Volume 41, Issue 1, pp 84–87 | Cite as

Small Cell Carcinoma of the Gall Bladder: Role of Adjuvant Chemotherapy

  • Saad Usmani
  • Mohammad Pazooki
  • Syed Fazil Bilgrami
BRIEF COMMUNICATION

Abstract

Introduction

Small cell cancer of the gallbladder is a rare malignancy with a poor prognosis. There is limited information in the literature on the best therapeutic approach towards this cancer with anecdotal therapy extrapolated from experience in small cell cancer of the lung.

Case Report

We are presenting a 70-year-old woman with this cancer who is undergoing multimodality treatment, along with a review of literature on previously reported cases.

Keywords

small cell cancer gallbladder chemotherapy 

References

  1. 1.
    van der Heijden HF, Heijdra YF. Extrapulmonary small cell carcinoma. South Med J. 2005;98:345–9.CrossRefPubMedGoogle Scholar
  2. 2.
    Mckeown F. Oat-cell carcinoma of the esophagus. J Pathol Bacteriol. 1952;80:889–91.CrossRefGoogle Scholar
  3. 3.
    Brenner B, Tang LH, Klimstra DS, et al. Small-cell carcinomas of the gastrointestinal tract: a review. J Clin Oncol. 2004;22:2730–9.CrossRefPubMedGoogle Scholar
  4. 4.
    Albores-Saavedra J, Cruz-Ortiz H, Alcantara-Vazques A, et al. Unusual types of gallbladder carcinoma. A report of 16 cases. Arch Pathol Lab Med. 1981;105:287–93.PubMedGoogle Scholar
  5. 5.
    Bahadur S, Shaukat A, Gibbs J, et al. Cisplatin and gemcitabine for small cell carcinoma of the gall bladder. Am J Clin Oncol. 2005;28:425–6.CrossRefPubMedGoogle Scholar
  6. 6.
    Moskal TL, Zhang PJ, Nava HR. Small cell carcinoma of the gallbladder. J Surg Oncol. 1999;70:54–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Guo KJ, Yamaguchi K, Enjoji M. Undifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis. Cancer. 1988;61:1872–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Albores-Saavedra J, Soriano J, Larraza-Hernandez O, et al. Oat cell carcinoma of the gallbladder. Hum Pathol. 1984;15:639–46.CrossRefPubMedGoogle Scholar
  9. 9.
    Friedman MD, Wheeler WE. Cancer of the gallbladder. South Med J. 1990;83:485–6.PubMedGoogle Scholar
  10. 10.
    Cavazzana AO, Fassina AS, Tollot M, et al. Small-cell carcinoma of gallbladder. An immunocytochemical and ultrastructural study. Pathol Res Pract. 1991;187:472–6.PubMedGoogle Scholar
  11. 11.
    Iida Y, Tsutsumi Y. Small cell (endocrine cell) carcinoma of the gallbladder with squamous and adenocarcinomatous components. Acta Pathol Jpn. 1992;42:119–25.PubMedGoogle Scholar
  12. 12.
    Ron IG, Wigler N, Ilie B, Chaitchik S. Small cell carcinoma of the gallbladder: clinical course and response to chemotherapy. Tumori. 1992;78:207–10.PubMedGoogle Scholar
  13. 13.
    Johnstone AK, Zuch RH, Anders KH. Oat cell carcinoma of the gallbladder. A rare and highly lethal neoplasm. Arch Pathol Lab Med. 1993;117:1009–12.PubMedGoogle Scholar
  14. 14.
    Nishihara K, Tsuneyoshi M. Undifferentiated spindle cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and flow cytometric study of 11 cases. Hum Pathol. 1993;24:1298–305.CrossRefPubMedGoogle Scholar
  15. 15.
    Muraina OI, Tank R, Dhingra C, Vuletin JC, Colella F, Abdelsayed G, et al. Small cell carcinoma of gallbladder: report of two cases. Am J Gastroenterol. 1996;91:792–4.PubMedGoogle Scholar
  16. 16.
    Debois JM, De Vriendt P, Charels K. Small cell carcinoma of the gallbladder. Acta Chir Belg. 1998;98:110–2.PubMedGoogle Scholar
  17. 17.
    Kuwabara H, Uda H. Small cell carcinoma of the gall-bladder with intestinal metaplastic epithelium. Pathol Int. 1998;48:303–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Matsuo S, Shinozaki T, Yamaguchi S, et al. Small-cell carcinoma of the gallbladder: report of a case. Surg Today. 2000;30:89–93.CrossRefPubMedGoogle Scholar
  19. 19.
    Maitra A, Tascilar M, Hruban RH, et al. Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J Surg Pathol. 2001;25:595–601.CrossRefPubMedGoogle Scholar
  20. 20.
    Fujii H, Aotake T, Horiuchi T, et al. Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature. Hepatogastroenterology. 2001;48:1588–93.PubMedGoogle Scholar
  21. 21.
    Lane JE, Walker AN, Ayers GW, et al. Small-cell undifferentiated carcinoma of neuroendocrine type originating in the gallbladder. Curr Surg. 2002;59:495–7.CrossRefPubMedGoogle Scholar
  22. 22.
    Jun SR, Lee JM, Han JK, et al. High-grade neuroendocrine carcinomas of the gallbladder and bile duct: Report of four cases with pathological correlation. J Comput Assist Tomogr. 2006;30:604–9.CrossRefPubMedGoogle Scholar
  23. 23.
    Imai H, Matsui S, Tokuyama Y, et al. Small cell carcinoma of the gallbladder successfully treated by surgery and adjuvant chemotherapy. Am Surg. 2008;74:272–3.PubMedGoogle Scholar
  24. 24.
    Iype S, Mirza TA, Propper DJ, et al. Neuroendocrine tumours of the gallbladder: three cases and a review of the literature. Postgrad Med J. 2009;85:213–8.CrossRefPubMedGoogle Scholar
  25. 25.
    Uribe-Uribe NO, Jimenez-Garduño AM, Henson DE, et al. Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder. Ann Diagn Pathol. 2009;13:124–6.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Saad Usmani
    • 1
  • Mohammad Pazooki
    • 1
  • Syed Fazil Bilgrami
    • 2
    • 3
  1. 1.Division of Hematology-OncologyUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Division of Hematology-OncologySt. Francis HospitalHartfordUSA
  3. 3.University of Connecticut School of MedicineFarmingtonUSA

Personalised recommendations