Association of HTLV1 Infection and Esophageal Squamous Cell Carcinoma
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Both esophageal carcinoma and HTLV-1 (Human T cell lymphotropic virus 1) have high prevalence in northeastern of Iran.
To assess the presence of HTLV-1 genome in esophageal cancerous tissue and in tissues from non cancerous individuals.
Eighty five patients with esophageal squamous cell carcinoma and 48 non-cancerous control patients that underwent esophagogasteroscopy for other reasons were included in this study. All selected subjects are residing in northeastern part of Iran. All specimens were studied histopathologically by H&E staining and were evaluated for HTLV-1 by PCR method. In PCR, the presence of tax, pol, env and LTR segments of HTLV-1 genome were detected.
Male to female ratio in the case group was 3 to 5. Average age and standard deviation in case and control group were 56 ± 17 and 54 ± 21 years, respectively; which did not have any significant differences. All the patients came from the same area in the northeastern part of Iran. HTLV-1 genome was found in two subjects with esophageal cancer and in one subject in the control group. Statistical analysis showed no significant differences between the two groups (chi square = 0.26, Fisher exact test P value = 0.7, Odd ratio = 1.13 [0.08 < OR < 32.46]).
HTLV-1 infection and esophageal squamous cell carcinoma did not appear to have a significant correlation.
Keywordsesophageal squamous cell carcinoma HTLV-1 Iran P53 pRb cyclin D1
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