Journal of Gastrointestinal Cancer

, Volume 38, Issue 1, pp 15–18

Association of HTLV1 Infection and Esophageal Squamous Cell Carcinoma

  • M. Mirsadraee
  • M. R. Kalantari
  • A. Saffari
  • M. Mahmoudi



Both esophageal carcinoma and HTLV-1 (Human T cell lymphotropic virus 1) have high prevalence in northeastern of Iran.


To assess the presence of HTLV-1 genome in esophageal cancerous tissue and in tissues from non cancerous individuals.


Eighty five patients with esophageal squamous cell carcinoma and 48 non-cancerous control patients that underwent esophagogasteroscopy for other reasons were included in this study. All selected subjects are residing in northeastern part of Iran. All specimens were studied histopathologically by H&E staining and were evaluated for HTLV-1 by PCR method. In PCR, the presence of tax, pol, env and LTR segments of HTLV-1 genome were detected.


Male to female ratio in the case group was 3 to 5. Average age and standard deviation in case and control group were 56 ± 17 and 54 ± 21 years, respectively; which did not have any significant differences. All the patients came from the same area in the northeastern part of Iran. HTLV-1 genome was found in two subjects with esophageal cancer and in one subject in the control group. Statistical analysis showed no significant differences between the two groups (chi square = 0.26, Fisher exact test P value = 0.7, Odd ratio = 1.13 [0.08 < OR < 32.46]).


HTLV-1 infection and esophageal squamous cell carcinoma did not appear to have a significant correlation.


esophageal squamous cell carcinoma HTLV-1 Iran P53 pRb cyclin D1 


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Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • M. Mirsadraee
    • 1
    • 2
    • 8
  • M. R. Kalantari
    • 3
    • 4
  • A. Saffari
    • 2
    • 5
  • M. Mahmoudi
    • 6
    • 7
  1. 1.Department of Internal MedicineMedical School of Islamic Azad University of MashhadMashhadIran
  2. 2.Aria HospitalMashhadIran
  3. 3.Department of PathologyMashhad University of Medical SciencesMashhadIran
  4. 4.Department of PathologyMashhad University of Medical Sciences, Ghaem HospitalMashhadIran
  5. 5.GI Diseases Division, Department of Internal MedicineMedical School of Islamic Azad University of MashhadMashhadIran
  6. 6.Immunology Research Center, BuAli Research InstituteMashhad University of Medical SciencesMashhadIran
  7. 7.Buali Resrach CenterMashhadIran
  8. 8.MashhadIran

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