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Cerebral Vascular Changes During Acute Intracranial Pressure Drop

  • Xiuyun Liu
  • Lara L. Zimmermann
  • Nhi Ho
  • Paul Vespa
  • Xiaoling Liao
  • Xiao Hu
Original Article

Abstract

Objective

This study applied a new external ventricular catheter, which allows intracranial pressure (ICP) monitoring and cerebral spinal fluid (CSF) drainage simultaneously, to study cerebral vascular responses during acute CSF drainage.

Methods

Six patients with 34 external ventricular drain (EVD) opening sessions were retrospectively analyzed. A published algorithm was used to extract morphological features of ICP recordings, and a template-matching algorithm was applied to calculate the likelihood of cerebral vasodilation index (VDI) and cerebral vasoconstriction index (VCI) based on the changes of ICP waveforms during CSF drainage. Power change (∆P) of ICP B-waves after EVD opening was also calculated. Cerebral autoregulation (CA) was assessed through phase difference between arterial blood pressure (ABP) and ICP using a previously published wavelet-based algorithm.

Results

The result showed that acute CSF drainage reduced mean ICP (P = 0.016) increased VCI (P = 0.02) and reduced ICP B-wave power (P = 0.016) significantly. VCI reacted to ICP changes negatively when ICP was between 10 and 25 mmHg, and VCI remained unchanged when ICP was outside the 10–25 mmHg range. VCI negatively (r = − 0.44) and VDI positively (r = 0.82) correlated with ∆P of ICP B-waves, indicating that stronger vasoconstriction resulted in bigger power drop in ICP B-waves. Better CA prior to EVD opening triggered bigger drop in the power of ICP B-waves (r = − 0.612).

Conclusions

This study demonstrates that acute CSF drainage reduces mean ICP, and results in vasoconstriction which can be detected through an index, VCI. Cerebral vessels actively respond to ICP changes or cerebral perfusion pressure (CPP) changes in a certain range; beyond which, the vessels are insensitive to the changes in ICP and CPP.

Keywords

Cerebral autoregulation Cerebrospinal fluid drainage Cerebral vascular changes Intracranial pressure waveform ICP B-waves 

Notes

Author Contributions

The concept and study design were formed by X.H., X.Y.L., P.V., L.Z. and X.L.L. Data acquisition was conducted by P.V., N.H. and L.Z. Data analysis was conducted by X.Y.L., N.H., X.L.L and X.H. Drafting of the manuscript and figures was contributed by X.Y.L., X.H., L.Z., P.V., N.H. and X.L.L.

Source of support

This work was partially supported by the UCSF Middle Career Scientist Award, UCSF Institute for Computational Health Sciences, and National Institutes of Health awards (R01NS076738 and NS106905-01A1).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

The institutional review board (IRB) approved the data analysis and waived the need for consenting patients because of the retrospective nature of the study.

Supplementary material

12028_2018_651_MOESM1_ESM.docx (64 kb)
Supplementary material 1 (DOCX 64 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2018

Authors and Affiliations

  1. 1.Department of Physiological NursingUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Neurosurgery, School of MedicineUniversity of CaliforniaLos AngelesUSA
  3. 3.Department of Neurological SurgeryUniversity of CaliforniaDavisUSA
  4. 4.Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection TechnologyInstitute of Biomedical Engineering, Chongqing University of Science and TechnologyChongqingPeople’s Republic of China
  5. 5.Department of Neurological SurgeryUniversity of CaliforniaSan FranciscoUSA
  6. 6.Institute of Computational Health Sciences, University of CaliforniaSan FranciscoUSA

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