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Neurocritical Care

, Volume 30, Issue 3, pp 675–680 | Cite as

Loss of Vestibular Ocular Reflex in Nonconvulsive Status Epilepticus

  • Jennifer H. KangEmail author
  • Aatif M. Husain
  • Joel C. Morgenlander
Practical Pearl

Abstract

Background

Electroencephalogram (EEG) findings of generalized periodic discharges (GPDs) with triphasic morphology were introduced as a metabolic phenomenon, but more recently have been associated with epileptic phenomenon. Resolution of EEG findings along with clinical improvement from treatment is diagnostic. The known causes of reversible, isolated loss of OVR include medication toxicity, lead exposure, and thiamine deficiency, but its association with nonconvulsive status epilepticus (NCSE) has never been published. Medication induced loss of OVR resolves after a 24-hour washout period. We report a case of reversible, isolated loss of vestibular ocular reflex (VOR) associated with epileptic phenomenon.

Methods

This is a case report of a single patient.

Results

A 74-year-old male with a history of complex partial seizures admitted for a pneumonectomy had a post-operative course complicated by two instances of coma, the latter associated with an isolated loss of VOR. EEG revealed GPDs with triphasic morphology initially interpreted as a metabolic phenomenon. The patient’s mental status, exam and EEG findings improved after low dose infusion of propofol for tracheostomy, and he was eventually discharged at baseline neurological function. Due to this response, his coma, loss of VOR and EEG were later interpreted as a consequence of NCSE.

Conclusion

The interpretation of GPDs with triphasic wave morphology range from metabolic phenomenon to NCSE. NCSE should be highly considered on the differential for encephalopathy regardless of the circumstances. NCSE may be a potential cause of reversible, isolated loss of the VOR and an AED trial in the appropriate clinical context should be considered. This is the first report of loss of VOR possibly associated with NCSE.

Notes

Author Contributions

Jennifer Kang was the lead author and performed the literature review with substantive contributions of expertise and editing by Joel Morgenlander and Aatif Husain. Jennifer Kang and Joel Morgenlander identified the case on clinical rounds. Aatif Husain obtained the necessary figures. All authors finalized the last version.

Source of Support

None to declare.

Compliance with Ethical Standards

Conflict of interest

The authors declare there were no conflicts of interest.

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2018

Authors and Affiliations

  • Jennifer H. Kang
    • 1
    Email author
  • Aatif M. Husain
    • 1
    • 2
    • 3
  • Joel C. Morgenlander
    • 1
  1. 1.Department of NeurologyDuke University Medical CenterDurhamUSA
  2. 2.Neurodiagnostic CenterVeterans Affairs Medical CenterDurhamUSA
  3. 3.Neuroscience MedicineDuke Clinical Research InstituteDurhamUSA

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