Neurocritical Care

, Volume 29, Issue 3, pp 508–511 | Cite as

Medulla Oblongata Hemorrhage and Reverse Takotsubo Cardiomyopathy

  • Kevin T. Gobeske
  • Maurice E. Sarano
  • Jennifer E. Fugate
  • Eelco F. WijdicksEmail author
Practical Pearl



Acute brain injury with strong surges of adrenergic outflow has resulted in takotsubo cardiomyopathy, but there are surprisingly few reports of takotsubo cardiomyopathy after intracranial hemorrhage, and none have been described from hemorrhage within the brainstem.


We describe a patient with reverse and reversible cardiomyopathy following a hemorrhage in the lateral medulla oblongata. While it is limited in size, the location of the hemorrhage caused acute systolic failure with left ventricular ejection fraction of 27% and vasopressor requirement for cardiogenic shock and pulmonary edema. There was full recovery after 7 days.


Detailed case report.


Hemorrhage into medulla oblongata pressor centers may result in acute, reversible, stress-induced cardiomyopathy, affirming the adrenergic origin of this condition.


Takotsubo cardiomyopathy Intracranial hemorrhage Medulla oblongata Neurogenic cardiac injury 


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Kevin T. Gobeske
    • 1
  • Maurice E. Sarano
    • 2
  • Jennifer E. Fugate
    • 1
  • Eelco F. Wijdicks
    • 1
    Email author
  1. 1.Division of Critical Care Neurology, Division of Neurocritical Care, Department of NeurologyMayo ClinicRochesterUSA
  2. 2.Division of Cardiology, Department of MedicineMayo ClinicRochesterUSA

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