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Neurocritical Care

, Volume 26, Issue 2, pp 174–181 | Cite as

The Effect of Positive End-Expiratory Pressure on Intracranial Pressure and Cerebral Hemodynamics

  • Myles D. Boone
  • Sayuri P. Jinadasa
  • Ariel Mueller
  • Shahzad Shaefi
  • Ekkehard M. Kasper
  • Khalid A. Hanafy
  • Brian P. O’Gara
  • Daniel S. Talmor
Original Article

Abstract

Background

Lung protective ventilation has not been evaluated in patients with brain injury. It is unclear whether applying positive end-expiratory pressure (PEEP) adversely affects intracranial pressure (ICP) and cerebral perfusion pressure (CPP). We aimed to evaluate the effect of PEEP on ICP and CPP in a large population of patients with acute brain injury and varying categories of acute lung injury, defined by PaO2/FiO2.

Method

Retrospective data were collected from 341 patients with severe acute brain injury admitted to the ICU between 2008 and 2015. These patients experienced a total of 28,644 paired PEEP and ICP observations. Demographic, hemodynamic, physiologic, and ventilator data at the time of the paired PEEP and ICP observations were recorded.

Results

In the adjusted analysis, a statistically significant relationship between PEEP and ICP and PEEP and CPP was found only among observations occurring during periods of severe lung injury. For every centimeter H2O increase in PEEP, there was a 0.31 mmHg increase in ICP (p = 0.04; 95 % CI [0.07, 0.54]) and a 0.85 mmHg decrease in CPP (p = 0.02; 95 % CI [−1.48, −0.22]).

Conclusion

Our results suggest that PEEP can be applied safely in patients with acute brain injury as it does not have a clinically significant effect on ICP or CPP. Further prospective studies are required to assess the safety of applying a lung protective ventilation strategy in brain-injured patients with lung injury.

Keywords

Acute brain injury Acute respiratory distress syndrome Cerebral perfusion pressure Intracranial pressure Intracranial hypertension Mechanical ventilation 

Notes

Funding information

This study was not funded by any grant.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Myles D. Boone
    • 1
  • Sayuri P. Jinadasa
    • 1
  • Ariel Mueller
    • 1
  • Shahzad Shaefi
    • 1
  • Ekkehard M. Kasper
    • 2
  • Khalid A. Hanafy
    • 3
  • Brian P. O’Gara
    • 1
  • Daniel S. Talmor
    • 1
  1. 1.Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA
  2. 2.Department of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA
  3. 3.Department of Neurology, Division of Neurocritical Care, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA

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