CSF Volumetric Analysis for Quantification of Cerebral Edema After Hemispheric Infarction
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Malignant cerebral edema (CED) complicates at least 20 % of large hemispheric infarcts (LHI) and may result in neurological deterioration or death. Midline shift (MLS) is a standard but crude measure of edema severity. We propose that volumetric analysis of shifts in cerebrospinal fluid (CSF) over time provides a reliable means of quantifying the spectrum of edema severity after LHI.
We identified 38 patients from 2008 to 2014 with NIHSS ≥8, baseline CT <6 h after stroke onset, at least 1 follow-up (FU) CT, and no parenchymal hematoma. The volumes of CSF (sulci, ventricles, and cisterns) ipsilateral (IL) and contralateral (CL) to infarct on baseline and FU CTs were quantified by manually assisted outlining with MIPAV image analysis software, as was infarct volume and MLS on FU CTs. Percentage change in CSF volumes (∆CSF) from baseline to FU scans was correlated with MLS and compared in those with vs. without malignant edema (defined as hemicraniectomy, osmotic therapy, or death/neurological deterioration with MLS ≥5 mm).
11 of 38 subjects (29 %) developed malignant edema. Neither baseline NIHSS nor CSF volume differed between those with and without edema (median NIHSS 18 vs. 13, p = 0.12, CSF volume 102 vs. 124 ml, p = 0.16). Inter-rater reliability for CSF measurements was excellent (intraclass correlation coefficient 0.97). ∆CSF correlated strongly with MLS at peak edema (r = −0.75), even adjusting for infarct volume (p = 0.009). ∆CSF was also greater in those with malignant edema [−55 % (IQR −49 to −62) vs. −36 % (−27 to −45), p = 0.004]. ∆CSF was the greatest within IL sulci [−97 % (−86 to −99) vs. −71 % (−41 to −79), p = 0.002] but also significantly greater within CL sulci in those with malignant edema [−50 % (−29 to −65) vs. −25 % (0 to −31), p = 0.014]. More than half this CSF volume reduction occurred by the time of first FU CT around 24 h after stroke, while MLS rose later.
Volumetric CSF analysis reliably quantifies CED and distinguishes those with malignant edema and MLS from those with a more benign course after LHI. ∆CSF may provide an earlier and more sensitive indicator of edema severity across a broader dynamic range than MLS.
KeywordsStroke Brain edema Cerebrospinal fluid Neuroimaging
NIH KL2 (5KL2TR000450-08 and UL1 TR000448) to Rajat Dhar NINDS R01 (NS086419) to Jin-Moo Lee.
Compliance with Ethical Standards
The authors have no relevant financial disclosures (outside of funding support, as listed) to report.
- 4.Thomalla G, Hartmann F, Juettler E, Singer OC, Lehnhardt F-G, Köhrmann M, et al. Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: a prospective multicenter observational study. Ann Neurol. 2010;68:435–45.CrossRefPubMedGoogle Scholar
- 11.Fiorelli M, Bastianello S, von Kummer R, del Zoppo GJ, Larrue V, Lesaffre E, et al. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke. 1999;30:2280–4.CrossRefPubMedGoogle Scholar
- 14.Monro A. Observations on the structure and functions of the nervous system. Edinburgh: Creech and Johnson; 1783.Google Scholar
- 15.Burrows G. On disorders of the cerebral circulation and on the connection between affections of the brain and diseases of the heart. Philadelphia: Lea & Blanchard; 1848.Google Scholar
- 16.Cushing H. The third circulation in studies in intracranial physiology and surgery. London: Oxford University Press; 1926. p. 1–51.Google Scholar