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Neurocritical Care

, Volume 23, Issue 3, pp 419–426 | Cite as

Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension

  • Chiara Robba
  • Joseph Donnelly
  • Rita Bertuetti
  • Danilo Cardim
  • Mypinder S. Sekhon
  • Marcel Aries
  • Peter Smielewski
  • Hugh Richards
  • Marek Czosnyka
Translational Research

Abstract

Background

In many neurological diseases, intracranial pressure (ICP) is elevated and needs to be actively managed. ICP is typically measured with an invasive transducer, which carries risks. Non-invasive techniques for monitoring ICP (nICP) have been developed. The aim of this study was to compare three different methods of transcranial Doppler (TCD) assessment of nICP in an animal model of acute intracranial hypertension.

Methods

In 28 rabbits, ICP was increased to 70–80 mmHg by infusion of Hartmann’s solution into the lumbar subarachnoid space. Doppler flow velocity in the basilar artery was recorded. nICP was assessed through three different methods: Gosling’s pulsatility index PI (gPI), Aaslid’s method (AaICP), and a method based on diastolic blood flow velocity (FVdICP).

Results

We found a significant correlation between nICP and ICP when all infusion experiments were combined (FVdICP: r = 0.77, AaICP: r = 0.53, gPI: r = 0.54). The ability to distinguish between raised and ‘normal’ values of ICP was greatest for FVdICP (AUC 0.90 at ICP >40 mmHg). When infusion experiments were considered independently, FVdICP demonstrated again the strongest correlation between changes in ICP and changes in nICP (mean r = 0.85).

Conclusions

TCD-based methods of nICP monitoring are better at detecting changes of ICP occurring in time, rather than absolute prediction of ICP as a number. Of the studied methods of nICP, the method based on FVd is best to discriminate between raised and ‘normal’ ICP and to monitor relative changes of ICP.

Keywords

Intracranial pressure Transcranial Doppler Rabbit Pulsatility index 

Notes

Acknowledgement

Authors thank Mr. Spencer Harland and Dr. Stefan Piechnik for sharing recorded digital data from experiments.

Compliance with Ethical Standards

Conflict of interest

Marek Czosnyka and Peter Smielewski are co-authors of the ICM+ software (www.neurosurg.cam.ac.uk/icmplus) and receive licensing fees (Cambridge Enterprise Ltd, UK). Chiara Robba, Joseph Donnelly, Mypinder Sekhon, Marcel Aries, Rita Bertuetti, Danilo Cardim declare that they have no conflict of interest.

Ethical Standards

All animal studies have been approved by the appropriate ethics committee and have been performed in accordance of UK Animals Scientific Procedures Act of 1986.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Chiara Robba
    • 1
  • Joseph Donnelly
    • 2
  • Rita Bertuetti
    • 1
  • Danilo Cardim
    • 2
  • Mypinder S. Sekhon
    • 3
  • Marcel Aries
    • 2
  • Peter Smielewski
    • 2
  • Hugh Richards
    • 2
  • Marek Czosnyka
    • 2
  1. 1.Neurocritical Care UnitAddenbrooke’s Hospital, Cambridge University, Cambridge University Hospitals TrustCambridgeUK
  2. 2.Division of Neurosurgery, Department of Clinical NeurosciencesAddenbrooke’s Hospital, Cambridge University Hospitals TrustCambridgeUK
  3. 3.Department of Medicine, Division of Critical Care MedicineVancouver General Hospital, University of British ColumbiaVancouverCanada

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