Neurocritical Care

, Volume 23, Issue 1, pp 92–102 | Cite as

Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study

  • Celeste Dias
  • Maria João Silva
  • Eduarda Pereira
  • Elisabete Monteiro
  • Isabel Maia
  • Silvina Barbosa
  • Sofia Silva
  • Teresa Honrado
  • António Cerejo
  • Marcel J. H. Aries
  • Peter Smielewski
  • José-Artur Paiva
  • Marek Czosnyka
Original Article



Guidelines recommend cerebral perfusion pressure (CPP) values of 50–70 mmHg and intracranial pressure lower than 20 mmHg for the management of acute traumatic brain injury (TBI). However, adequate individual targets are still poorly addressed, since patients have different perfusion thresholds. Bedside assessment of cerebral autoregulation may help to optimize individual CPP-guided treatment.


To assess staff compliance and outcome impact of a new method of autoregulation-guided treatment (CPPopt) based on continuous evaluation of cerebrovascular reactivity (PRx).


Prospective pilot study of severe TBI adult patients managed with continuous multimodal brain monitoring in a single Neurocritical Care Unit (NCCU). Every minute CPPopt was automatically estimated, based on the previous 4-h window, as the CPP with the lowest PRx indicating the best cerebrovascular pressure reactivity. Patients were managed with CPPopt targets whenever possible and otherwise CPP was managed following general/international guidelines. In addition, other offline CPPopt estimates were calculated using cerebral oximetry (COx-CPPopt), brain tissue oxygenation (ORxs-CPPopt), and cerebral blood flow (CBFx-CPPopt).


Eighteen patients with a total multimodal brain monitoring time of 5,520 h were enrolled. During the total monitoring period, 11 patients (61 %) had a CPPopt U-shaped curve, 5 patients (28 %) had either ascending or descending curves, and only 2 patients (11 %) had no fitted curve. Real CPP correlated significantly with calculated CPPopt (r = 0.83, p < 0.0001). Preserved autoregulation was associated with greater Glasgow coma score on admission (p = 0.01) and better outcome (p = 0.01). We demonstrated that patients with the larger discrepancy (>10 mm Hg) between real CPP and CPPopt more likely have had adverse outcome (p = 0.04). Comparison between CPPopt and the other estimates revealed similar limits of precision. The lowest bias (−0.1 mmHg) was obtained with COx-CPPopt (NIRS).


Targeted individual CPP management at the bedside using cerebrovascular pressure reactivity seems feasible. Large deviation from CPPopt seems to be associated with adverse outcome. The COx-CPPopt methodology using non-invasive CO (NIRS) warrants further evaluation.


Traumatic brain injury Multimodal brain monitoring Cerebral perfusion pressure Cerebrovascular pressure reactivity Optimal cerebral perfusion pressure 



Authors would especially like to thank all the NCCU Nursing staff for their motivation in learning the optimal CPP algorithm and for the commitment to its correct application.

Conflict of interest

The software for brain monitoring ICM+ ( is licensed by the University of Cambridge (Cambridge Enterprise). Peter Smielewski and Marek Czosnyka have financial interests in a part of the licensing fee. All other authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Celeste Dias
    • 1
  • Maria João Silva
    • 2
  • Eduarda Pereira
    • 1
  • Elisabete Monteiro
    • 1
  • Isabel Maia
    • 1
  • Silvina Barbosa
    • 1
  • Sofia Silva
    • 1
  • Teresa Honrado
    • 1
  • António Cerejo
    • 3
  • Marcel J. H. Aries
    • 4
  • Peter Smielewski
    • 5
  • José-Artur Paiva
    • 1
  • Marek Czosnyka
    • 5
  1. 1.Neurocritical Care Unit, Intensive Care DepartmentHospital Sao JoaoPortoPortugal
  2. 2.Diabetes & Nutritional Sciences DivisionKing’s CollegeLondonUK
  3. 3.Neurosurgery DepartmentHospital Sao JoaoPortoPortugal
  4. 4.Intensive Care/Critical Care UnitUniversitair Medisch CentrumGroningenThe Netherlands
  5. 5.Division of Neurosurgery, Department of Clinical NeurosciencesAddenbrooke’s HospitalCambridgeUK

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