Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury
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Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI.
We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality.
A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001).
In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality.
KeywordsOptic nerve sheath diameter Computed tomography Traumatic brain injury Intracranial pressure Cerebral spinal fluid
We would like to acknowledge the staff of the Vancouver General and Royal Columbian Hospitals for their support in the completion of this study. Dr. Griesdale is funded by the VGH & UBC Hospital Foundation Best of Health Fund.
Conflict of interest
None to declare.
All human and animal studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
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