Neurocritical Care

, Volume 19, Issue 3, pp 299–305 | Cite as

Predictors of Late Neurological Deterioration After Spontaneous Intracerebral Hemorrhage

  • Weiping Sun
  • Wenqin Pan
  • Peter G. Kranz
  • Claire E. Hailey
  • Rachel A. Williamson
  • Wei Sun
  • Daniel T. Laskowitz
  • Michael L. James
Original Article

Abstract

Background

Although intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease, little is known about factors leading to neurological deterioration occurring beyond 48 h after hematoma formation. The purpose of this study was to characterize the incidence, consequences, and associative factors of late neurological deterioration (LND) in patients with spontaneous ICH.

Methods

Using the Duke University Hospital Neuroscience Intensive Care Unit database from July 2007 to June 2012, a cohort of 149 consecutive patients with spontaneous supratentorial ICH met criteria for analysis. LND was defined as a decrease of two or more points in Glasgow Coma Scale score or death during the period from 48 h to 1 week after ICH symptom onset. Unfavorable outcome was defined as a modified Rankin Scale score of >2 at discharge.

Results

Forty-three subjects (28.9 %) developed LND. Logistic regression models revealed hematoma volume (OR = 1.017, 95 % CI 1.003–1.032, p = 0.019), intraventricular hemorrhage (OR = 2.519, 95 % CI 1.142–5.554, p = 0.022) and serum glucose on admission (OR = 2.614, 95 % CI 1.146–5.965, p = 0.022) as independent predictors of LND. After adjusting for ICH score, LND was independently associated with unfavorable outcome (OR = 4.000, 95 % CI 1.280–12.500, p = 0.017). In 65 subjects with follow-up computed tomography images, an increase in midline shift, as a surrogate for cerebral edema, was independently associated with LND (OR = 3.822, 95 % CI 1.157–12.622, p = 0.028).

Conclusions

LND is a common phenomenon in patients with ICH; further, LND appears to affect outcome. Independent predictors of LND include hematoma volume, intraventricular hemorrhage, and blood glucose on admission. Progression of perihematomal edema may be one mechanism for LND.

Keywords

Intracerebral hemorrhage Neurological deterioration Predictors Outcome Brain edema 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Weiping Sun
    • 1
    • 6
  • Wenqin Pan
    • 1
  • Peter G. Kranz
    • 2
  • Claire E. Hailey
    • 3
  • Rachel A. Williamson
    • 3
  • Wei Sun
    • 6
  • Daniel T. Laskowitz
    • 1
    • 3
    • 4
    • 5
  • Michael L. James
    • 3
    • 4
    • 5
  1. 1.Duke Clinical Research InstituteDuke UniversityDurhamUSA
  2. 2.Department of Radiology (Neuroradiology)Duke UniversityDurhamUSA
  3. 3.Department of AnesthesiologyDuke UniversityDurhamUSA
  4. 4.Department of NeurologyDuke UniversityDurhamUSA
  5. 5.Brain Injury Translational Research CenterDuke UniversityDurhamUSA
  6. 6.Department of NeurologyPeking University First HospitalBeijingPeople’s Republic of China

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