Neurocritical Care

, Volume 13, Issue 2, pp 182–189 | Cite as

Impact of Systemic Inflammatory Response Syndrome on Vasospasm, Cerebral Infarction, and Outcome After Subarachnoid Hemorrhage: Exploratory Analysis of CONSCIOUS-1 Database

  • Alan K. H. Tam
  • Don Ilodigwe
  • Jay Mocco
  • Stephan Mayer
  • Neal Kassell
  • Daniel Ruefenacht
  • Peter Schmiedek
  • Stephan Weidauer
  • Alberto Pasqualin
  • R. Loch MacdonaldEmail author
Original Article



Systemic inflammatory response syndrome (SIRS) may develop after aneurysmal subarachnoid hemorrhage (SAH). We investigated factors associated with SIRS after SAH, whether SIRS was associated with complications of SAH such as vasospasm, cerebral infarction, and clinical outcome, and whether SIRS could contribute to a difference in outcome between patients treated by endovascular coiling or neurosurgical clipping of the ruptured aneurysm.


This was exploratory analysis of 413 patients in the CONSCIOUS-1 study. SIRS was diagnosed if the patient had at least 2 of 4 variables (hypothermia/fever, tachycardia, tachypnea, and leukocytosis/leukopenia) within 4 days of admission. Clinical outcome was measured on the Glasgow outcome scale 3 months after SAH. The relationship between clinical and radiologic variables and SIRS, angiographic vasospasm, delayed ischemic neurologic deficit (DIND), cerebral infarction, vasospasm-related infarction, and clinical outcome were modeled with uni- and multivariable analyses.


63% of patients developed SIRS. Many factors were associated with SIRS in univariate analysis, but only poor WFNS grade and pneumonia were independently associated with SIRS in multivariable analysis. SIRS burden (number of SIRS variables per day over the first 4 days) was associated with poor outcome, but not with angiographic vasospasm, DIND, or cerebral infarction. The method of aneurysm treatment was not associated with SIRS.


SIRS was associated with poor outcome but not angiographic vasospasm, DIND, or cerebral infarction after SAH in the CONSCIOUS-1 data. There was no support for the notion that neurosurgical clipping is associated with a greater risk of SIRS than endovascular coiling.


Subarachnoid hemorrhage Inflammation Vasospasm Cerebral infarction 



Actelion Pharmaceuticals, Ltd., was the sponsor of the CONSCIOUS-1 trial. No financial support was provided for the exploratory analysis described in this article; the data analysis and writing are the work of the authors.

Conflict of interest statement



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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Alan K. H. Tam
    • 1
    • 2
  • Don Ilodigwe
    • 1
    • 2
  • Jay Mocco
    • 1
    • 2
  • Stephan Mayer
    • 1
    • 2
  • Neal Kassell
    • 1
    • 2
  • Daniel Ruefenacht
    • 1
    • 2
  • Peter Schmiedek
    • 1
    • 2
  • Stephan Weidauer
    • 1
    • 2
  • Alberto Pasqualin
    • 1
    • 2
  • R. Loch Macdonald
    • 1
    • 2
    Email author
  1. 1.Division of NeurosurgerySt. Michael’s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s HospitalTorontoCanada
  2. 2.Department of SurgeryUniversity of TorontoTorontoCanada

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