Neurocritical Care

, Volume 12, Issue 1, pp 35–42 | Cite as

Cerebral Autoregulation is Influenced by Carbon Dioxide Levels in Patients with Septic Shock

  • Fabio Silvio Taccone
  • Diego Castanares-Zapatero
  • Daliana Peres-Bota
  • Jean-Louis Vincent
  • Jacques Berre’
  • Christian Melot
Original Article



Altered brain perfusion may play an important role in the development of sepsis-associated encephalopathy. However, whether or not cerebral autoregulation (CA) is preserved in such condition has been debated. CA is dependent on cerebral vascular tone, the main determinant of which is the concentration of carbon dioxide (CO2). The purpose of this study was to evaluate the influence of PaCO2 on the cerebral autoregulatory capacity in patients with septic shock.


Using transcranial Doppler sonography recordings from the middle cerebral artery (MCA), we evaluated the static cerebral autoregulatory responses within the first 3 days of septic shock. Changes in cerebrovascular resistance (CVR) were calculated from the changes in the mean velocity in the MCA (VMCA, cm/s), in response to an increase in mean arterial pressure (MAP, mmHg) induced by vasopressors. The cerebral autoregulation index (CAI) was calculated as the ratio of the relative changes in CVR and MAP (CAI = ΔMAP%/ΔCVR%), with normal values ranging between 0 and 2.


We studied 21 mechanically ventilated patients, with a baseline MAP of 65 ± 6 mmHg, a mean VMCA of 60 ± 20 cm/s and a median PaCO2 of 35 [28–49] mmHg. Fourteen of the 21 patients had impaired CA, including 7 of the 14 patients with a PaCO2 <40 mmHg and all 7 patients with a PaCO2 >40 mmHg (Fisher’s exact test, P = 0.046).


According to these data, CA is impaired in the majority of patients with septic shock, especially in the presence of hypercapnia.


Sepsis Encephalopathy Cerebral blood flow Carbon dioxide Vascular reactivity 


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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Fabio Silvio Taccone
    • 1
  • Diego Castanares-Zapatero
    • 1
  • Daliana Peres-Bota
    • 1
  • Jean-Louis Vincent
    • 1
  • Jacques Berre’
    • 1
  • Christian Melot
    • 1
  1. 1.Department of Intensive CareErasme University Hospital, Université Libre de Bruxelles (ULB)BrusselsBelgium

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