Neurocritical Care

, Volume 9, Issue 1, pp 118–121

Recurrent Takotsubo Cardiomyopathy Triggered by Convulsive Status Epilepticus

  • Stephane Legriel
  • Fabrice Bruneel
  • Ludovic Dalle
  • Corinne Appere-de-Vecchi
  • Jean Louis Georges
  • Nathalie Abbosh
  • Matthieu Henry-Lagarrigue
  • Laure Revault D’Allonnes
  • Hager Ben Mokhtar
  • Juliette Audibert
  • Pierre Guezennec
  • Gilles Troche
  • Jean Pierre Bedos
Practical Pearl



Takotsubo cardiomyopathy can complicate several conditions including neurological emergencies. A few recurrent cases associated with seizures have been reported, but none of the patients had status epilepticus. The pathophysiology of takotsubo syndrome, although debated, may involve stunning of the myocardium by a catecholamine storm triggered by stress. Patients with epilepsy may be at increased risk for takotsubo syndrome, which may occur repeatedly.


We report on a postmenopausal woman with symptomatic epilepsy who experienced recurrent takotsubo cardiomyopathy triggered by convulsive status epilepticus. Brief seizures were not associated with takotsubo syndrome. The relevant literature was reviewed.


Over a 1-year period, she experienced two episodes of convulsive status epilepticus with complete neurological recovery after treatment. Echocardiography showed latero-septo-apical hypokinesia and apical ballooning. The cardiac abnormalities resolved fully and she recovered her baseline level of self-sufficiency. During the same period, she experienced several brief seizures, with no cardiac manifestations.


The occurrence of takotsubo cardiomyopathy in association with convulsive status epilepticus, but not with brief seizures, supports neurogenically mediated myocardial stunning related to direct toxicity of endogenous catecholamines. Neuro-intensivists must be aware of this potentially fatal but fully reversible cardiac complication, which may be among the causes of death in patients with status epilepticus.


Status epilepticus Takotsubo cardiomyopathy Intensive care unit Catecholamines Seizures 


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Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Stephane Legriel
    • 1
  • Fabrice Bruneel
    • 1
  • Ludovic Dalle
    • 2
  • Corinne Appere-de-Vecchi
    • 3
  • Jean Louis Georges
    • 4
  • Nathalie Abbosh
    • 1
  • Matthieu Henry-Lagarrigue
    • 1
  • Laure Revault D’Allonnes
    • 1
  • Hager Ben Mokhtar
    • 1
  • Juliette Audibert
    • 1
  • Pierre Guezennec
    • 1
  • Gilles Troche
    • 1
  • Jean Pierre Bedos
    • 1
  1. 1.Service de Réanimation PolyvalenteHôpital André Mignot, Centre Hospitalier de VersaillesLe Chesnay CedexFrance
  2. 2.Service des UrgencesHôpital André MignotLe Chesnay CedexFrance
  3. 3.Service de Réanimation PolyvalenteCentre Hospitalier de PoissyPoissy CedexFrance
  4. 4.Service de cardiologieHôpital André MignotLe Chesnay CedexFrance

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