Rapid Blood Pressure Reduction in Acute Intracerebral Hemorrhage: Feasibility and Safety
The optimal blood pressure (BP) for treating acute intracerebral hemorrhage remains (ICH) uncertain. High BP may contribute to hematoma growth while excessive BP reduction might precipitate peri-hemorrhage ischemia. We examine here the feasibility and safety of reducing BP to lower than presently recommended levels in patients with acute ICH.
Patients with ICH were prospectively randomized to standard BP treatment (mean arterial BP [MAP] 110–130 mmHg) or aggressive BP lowering (MAP < 110 mmHg) within 8 h of symptom onset. MAP was managed during the 48 h treatment period. NIHSS was obtained at baseline, 24, and 48 h. Brain CT was done 24 h after symptoms. A modified Rankin Scale (mRs) was obtained at 90 days. A clinical decline (NIHSS drop ≥ 2 points) within the first 48 h was the primary endpoint. Hematoma enlargement at 24 h was a secondary endpoint.
We enrolled 21 patients into each group. Mean age was 60.6 ± 12.3 years and MAP on presentation was 147.6 ± 18.2 mmHg. Treatment was started on average 3.2 ± 2.2 h after symptom onset. Baseline clinical variables were identical between the 2 treatment groups. Target blood pressure was achieved within 87.1 ± 59.6 min in the standard group and 163.5 ± 163.8 min in the aggressive BP treatment group. There were no significant differences in early neurological deterioration, hematoma and edema growth, and clinical outcome at 90 days.
A more aggressive reduction of acute hypertension after ICH does not increase the rate of neurological deterioration even when treatment is initiated within hours of symptom onset. Lowering BP aggressively did not affect hematoma and edema expansion but this possibility deserves further study.
KeywordsIntracerebral hemorrhage Hypertension Hematoma growth
- 1.Broderick JP, Adams HP Jr., Barsan W, Feinberg W, Feldmann E, Grotta J, Kase C, Krieger D, Mayberg M, Tilley B, Zabramski JM, Zuccarello M. Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the stroke council, American Heart Association Stroke 1999;30(4):905–15.PubMedGoogle Scholar
- 2.Priorities for clinical research in intracerebral hemorrhage: report from a National Institute of Neurological Disorders and Stroke Workshop. Stroke 2005;36(3):e23–41.Google Scholar
- 23.Qureshi AI, Mohammad YM, Yahia AM, Suarez JI, Siddiqui AM, Kirmani JF, Suri MF, Kolb J, Zaidat OO. A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage. J Intensive Care Med. 2005;20(1):34–42.PubMedCrossRefGoogle Scholar
- 24.Broderick J, Connolly S, Feldmann E, Hanley D, Kase C, Krieger D, Mayberg M, Morgenstern L, Ogilvy CS, Vespa P, Zuccarello M. Guidelines for the management of spontaneous intracerebral hemorrhage in adults. 2007 Update. A guideline from the American Heart Association, American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007;38(6):2001–23.PubMedCrossRefGoogle Scholar