Neurocritical Care

, Volume 8, Issue 3, pp 337–343 | Cite as

Aggressive Red Blood Cell Transfusion: No Association with Improved Outcomes for Victims of Isolated Traumatic Brain Injury

  • Mark E. GeorgeEmail author
  • David E. Skarda
  • Charles R. Watts
  • Hoai D. Pham
  • Greg J. Beilman



Clinical studies have caused blood transfusion practices in critically ill patients to become more conservative in the last decade. However, few studies have focused on trauma patients, particularly those with severe isolated traumatic brain injury.


We conducted a retrospective study to test the hypothesis that patients with severe brain injury would not benefit from aggressive red blood cell transfusion (RBCT). End points of the study were in-hospital mortality and morbidity (pneumonia, urinary tract infection, deep venous thrombosis, pulmonary embolus, decubitus ulcer, bacteremia, septic shock, myocardial infarction, and seizure). Included in our retrospective study were patients at two urban, level I trauma centers who were admitted with a diagnosis of isolated head injury and with a Glasgow Coma Scale (GCS) score of 8 or less. We recorded demographic, interventional, and outcome variables.


In 289 patients, 24 of 25 (96%) were transfused if their lowest recorded intensive care unit (ICU) hemoglobin level was 8.0 g/dl or less. In contrast, only 9/182 (5%) of these 289 patients were transfused if the hemoglobin levels were 10.0 g/dl or greater. In the remaining 82 patients with lowest ICU hemoglobin levels of 8.0–10.0 g/dl, 52% were transfused. These 82 patients (43 underwent RBCT and 39 did not) were included in our analysis.


The overall in-hospital mortality rate was 32%; rates were similar between the two groups (29%, non-RBCT; 35%, RBCT) (P = 0.64). Likewise, in-hospital morbidity was similar between groups. Logistic and proportional hazard regression analyses identified RBCT as one predictor of mortality.


Our results suggest that a restrictive transfusion practice is safe for severely head-injured patients.


Anemia Resuscitation Trauma Head injury Transfusion 


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Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Mark E. George
    • 1
    Email author
  • David E. Skarda
    • 1
  • Charles R. Watts
    • 2
  • Hoai D. Pham
    • 1
  • Greg J. Beilman
    • 1
    • 3
  1. 1.Department of Surgery, Division of Critical CareUniversity of Minnesota Medical Center, FairviewMinneapolisUSA
  2. 2.Department of SurgeryHennepin County Medical CenterMinneapolisUSA
  3. 3.North Memorial Medical CenterRobbinsdaleUSA

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