Effect of Endovascular Hypothermia on Acute Ischemic Edema: Morphometric Analysis of the ICTuS Trial
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Pilot studies of hypothermia for stroke suggest a potential benefit in humans. We sought to test whether hypothermia decreases post-ischemic edema using CT scans from a pilot trial of endovascular hypothermia for stroke.
Eighteen patients with acute ischemic stroke underwent therapeutic hypothermia (target = 33°C) for 12 or 24 h followed by a 12-h controlled re-warm using an endovascular system. CT scans obtained at baseline, 36–48 h (right after cooling and re-warming) and 30 days were digitized, intracranial compartment volumes measured using a validated stereological technique, and the calculated change in CSF volume between the three time-points were used as an estimate of edema formation in each patient. Patients were grouped retrospectively for analysis based on whether they cooled effectively (i.e., to a temperature nadir of less than 34.5°C within 8 h) or not.
Eleven patients were cooled partially or not at all, and seven were effectively cooled. Baseline demographics and compartment volumes and densities were similar in both groups. At 36–48 h, the total CSF volume had significantly decreased in the not-cooled group compared to the cooled group (P < 0.05), with no significant difference in mean volume of ischemia between them (73 ± 73 ml vs. 54 ± 59 ml, respectively), suggesting an ameliorative effect of hypothermia on acute edema formation. At 30 days, the difference in CSF volumes had resolved, and infarct volumes (73 ± 71 ml vs. 84 ± 102 ml, respectively) and functional outcomes were comparable.
Endovascular hypothermia decreases acute post-ischemic cerebral edema. A larger trial is warranted to determine if it affects final infarct volume and outcome in stroke.
KeywordsAcute stroke Induced hypothermia Brain edema Body temperature X-ray computed tomography
The Intravascular Cooling in the Treatment of Stroke (ICTuS) trial was sponsored by Innercool Inc. This study was supported by NS P50NS044148 (Lyden) and the Research Service of the Department of Veteran’s Affairs.
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