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Immunologic Research

, Volume 66, Issue 6, pp 737–743 | Cite as

Specific features of immune complexes in patients with sarcoidosis and pulmonary tuberculosis

  • Anna StarshinovaEmail author
  • Yu Zinchenko
  • M. Filatov
  • N. Denisova
  • E. Istomina
  • S. Landa
  • V. Burdakov
  • L. Churilov
  • N. Sapozhnikova
  • M. Pavlova
  • T. Stepanenko
  • V. Mayevskaya
  • P. Yablonskiy
Original Article

Abstract

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis. A prospective study was conducted with two groups of patients: group I (n = 50)—patients with pulmonary sarcoidosis established according to standard criteria; group II (n = 28)—patients with pulmonary tuberculosis with bacterial excretion. The control group (n = 24) was presented by healthy subjects. The examination complex included x-ray, bacteriological, immunological (Mantoux test with 2 TE, TB.SPOT test), and histological methods. All patients and healthy subjects were assessed for immune complexes with the use of the dynamic light scattering (DLS) method and adding of “healthy lung tissue extract” antigens and specific tuberculosis antigens ESAT-6 and SFP-10 in vitro. Significant differences were found in determining specific immune complexes in patients with pulmonary sarcoidosis and pulmonary tuberculosis. Registration of specific immune complex formation with “healthy lung tissue extract” in 100% cases may indicate the autoimmune nature of sarcoidosis. The absence of the immune complex formation in response to ESAT-6/SFP-10 antigens can be used for the differential diagnosis of two diseases. The diagnostic significance of the DLS method was 100% for sarcoidosis and 92.2% for tuberculosis. The data obtained in the study allows not only understanding the etiology of sarcoidosis, but also obtaining new criteria for the differential diagnosis of tuberculosis and pulmonary sarcoidosis.

Keywords

Sarcoidosis Tuberculosis Allergen test with tuberculosis recombinant Immunological tests Autoimmune diseases Dynamic light scattering method 

Notes

Compliance with ethical standards

The study was approved by the independent Ethics Committee of the FGBU “St. Petersburg Scientific Research Institute of Phthisiopulmonology” of the Ministry of Health of Russia Federation (protocol no. 34.2 dated January 19, 2017)

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Anna Starshinova
    • 1
    • 2
    Email author
  • Yu Zinchenko
    • 1
    • 2
  • M. Filatov
    • 1
    • 2
    • 3
  • N. Denisova
    • 1
  • E. Istomina
    • 1
  • S. Landa
    • 3
  • V. Burdakov
    • 1
    • 2
    • 3
  • L. Churilov
    • 1
    • 2
  • N. Sapozhnikova
    • 1
  • M. Pavlova
    • 1
  • T. Stepanenko
    • 4
  • V. Mayevskaya
    • 5
  • P. Yablonskiy
    • 1
    • 2
  1. 1.FGBU “St. Petersburg Scientific Research Institute of Phthisiopulmonology” of the Ministry of Health of RussiaSt. PetersburgRussia
  2. 2.The St. Petersburg State UniversitySt. PetersburgRussia
  3. 3.St. Petersburg Nuclear Physics Institute, NRC “Konstantinov Institute”GatchinaRussia
  4. 4.SPb GBUZ “City hospital №2”St. PetersburgRussia
  5. 5.The Saint Petersburg Federal State University of EconomicsSt. PetersburgRussia

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