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Tuftsin phosphorylcholine—a novel compound harnessing helminths to fight autoimmunity

  • Yahel Segal
  • Miri Blank
  • Yehuda ShoenfeldEmail author
Review
  • 78 Downloads

Abstract

The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. In an attempt to develop a novel therapeutic small molecule for the treatment of autoimmune conditions, we have conjugated PC with tuftsin, a natural immunomodulatory tetrapeptide, to create TPC. Herein, we review our findings regarding the effects of TPC in murine models of three autoimmune diseases—systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and rheumatic arthritis (RA), as well as ex-vivo samples from giant cell arteritis (GCA) patients. In all four disease models examined, TPC was shown to attenuate the inflammatory response by reducing expression of pro-inflammatory cytokines and altering the phenotype of T cell expression. In murine models, TPC has further produced a significant improvement in clinical disease scores with no significant side effects noted. Our findings suggest TPC presents promising potential as a novel therapeutic agent for the effective treatment of various autoimmune conditions.

Keywords

TPC Tuftsin Phosphorylcholine Helminths Worms SLE IBD RA GCA Immune modulation 

Abbreviations

TPC

Tuftsin-phosphorylcholine

GCA

Giant cell arteritis

IBD

Internal bowel disease

PBMCs

Periferal blood monouclear cells

RA

Rheumatoid arthritis

SLE

Systemic lupus erythematosus

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated with the Sackler Faculty of Medicine, Tel-Aviv UniversityTel AvivIsrael
  2. 2.Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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