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Antibody-initiated beneficial and harmful immune responses

  • Arpad Zsigmond Barabas
  • Chad Douglas Cole
  • Rene Lafreniere
Hypothesis

Abstract

A critical function of the immune system is to maintain tolerance to self by corrective immune responses throughout life, including preventing or correcting changes that may interfere with organ function and architectural integrity. These changes have two broad categories, namely (1) exogenous antigen-induced mishaps (e.g., due to bacterial, viral or fungal infections) and (2) endogenous antigen-caused ailments initiated by modified self-antigens derived from damaged organs following exposure to smoke, certain drugs, chemicals, infectious agents, radiation, etc., resulting in autoimmune diseases or cancer. In some cases, cells of the immune system are unable to respond with a corrective antibody response. For example, presentation of a modified self-antigen can initiate a pathogenic IgG immune response, thereby causing an autoimmune disease. Furthermore, if cancer-associated antigens are not appropriately presented to the cells of the immune system, there is failure to mount a specific pathogenic lytic IgG autoantibody response for recognition and elimination of cancer-associated antigens, and as a consequence, the cancer continues to proliferate.

The third vaccination technique that we have developed and designated a modified vaccination technique (MVT) is able to correct these immunological mishaps. The premise of the MVT is that it can prevent both exogenous (infectious and contagious diseases) and endogenous (autoimmune diseases and cancer) antigen-caused diseases, as well as terminate established diseases. Therefore, by exploiting the immune system’s natural abilities to make corrective responses, it has both prophylactic and therapeutic actions, with minimal side effects.

Keywords

Antibody-initiated beneficial Harmful immune responses 

Abbreviations

aab

Autoantibody

ab

Antibody

ag

Antigen

BB

Brush border

HN

Heymann nephritis

IC

Immune complex

ICGN

Immune complex glomerulonephritis

MM

Multiple myeloma

MVT

Modified vaccination technique

SPHN

Slowly progressive Heymann nephritis

MW

Molecular weight

Notes

Acknowledgements

We acknowledge the assistance of our research associate, Zoltan Kovacs, in computer and laboratory-related work.

Compliance of ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Arpad Zsigmond Barabas
    • 1
  • Chad Douglas Cole
    • 2
  • Rene Lafreniere
    • 1
  1. 1.Department of SurgeryUniversity of CalgaryAlbertaCanada
  2. 2.Department of NeurosurgeryUniversity of UtahSalt Lake CityUSA

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