T cell receptor-β J usage, in combination with particular HLA class II alleles, correlates with better cancer survival rates
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T cell receptor (TCR) β V and J usage correlates with either the HLA class I or HLA class II major histocompatibility subtypes, and in both infectious diseases and autoimmune settings, the use of particular TCR-β V and J’s, in persons with specific HLA alleles, represents either better outcomes or certain clinical features. However, the relationship of TCR V and J usage, HLA alleles, and clinical parameters in the cancer setting has been less well studied. Here, we have evaluated the relationship of what is likely dominant TCR-β V and J usage among tissue-resident lymphocytes for lung, head and neck, kidney, stomach, ovarian, and endometrial cancers, with patient HLA class II alleles. The most striking indication is that TCR-β J subgroup usage, in combination with particular patient HLA class II alleles, correlated with either better or worse outcomes for lung cancer. One combination, TCR-β J2 segment usage and the HLA-DRB1*1501 allele, correlated with a better survival rate for both lung and head and neck cancers. These results fill a gap in knowledge regarding the relevance of HLA typing to cancer and indicate that HLA typing, along with an indication of dominant TCR-β J usage among tissue-resident lymphocytes, can be useful for prognosis.
KeywordsT cell receptor-β HLA class I and class II proteins Antigen presentation Cancer immune response The Cancer Genome Atlas
Head and neck squamous carcinoma
Kidney and renal carcinoma
The Cancer Genome Atlast
Uterine corpus and endometrial carcinoma
Authors would like to acknowledge the support of USF Research Computing and the taxpayers of the State of Florida. BMC was a recipient of a Bonati scholarship.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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