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Immunologic Research

, Volume 59, Issue 1–3, pp 56–65 | Cite as

Regulation of T cell responses by the receptor molecule Tim-3

  • Jacob V. Gorman
  • John D. ColganEmail author
IMMUNOLOGY AT THE UNIVERSITY OF IOWA

Abstract

Tim-3 is a member of the T cell immunoglobulin and mucin domain (Tim) family of proteins, which are expressed by several cell types in the immune system, including CD4 and CD8 T cells activated under certain conditions. These molecules are generally thought to act as receptors for multiple ligands and thus to function by engaging intracellular signaling pathways in a ligand-dependent manner. In recent years, the function of the Tim-3 protein has been studied in some detail, particularly with respect to its role in the regulation of CD4 and CD8 T cell responses. Here, we review the structural features of Tim-3, known ligands for this molecule and the links established between Tim-3 and signal transduction pathways. In addition, we review the current literature regarding the role of Tim-3 in the regulation of effector responses by CD4 and CD8 T cells. Overall, findings published thus far strongly support the conclusion that Tim-3 functions to inhibit T cell responses, particularly under conditions involving chronic stimulation. Conversely, some reports have provided evidence that Tim-3 can stimulate T cells under conditions involving acute stimulation, suggesting that the role of Tim-3 may vary depending on context. Further study of Tim-3 is likely to advance our understanding of how CD4 and CD8 T cell responses are regulated and could uncover novel approaches for manipulating T cell function for therapeutic benefit.

Keywords

T cells Tim protein family Surface receptor Signal transduction Immune system regulation 

Notes

Acknowledgments

This work was supported by the following grants from the National Institutes: T32 AI007485 (to J.V.G.); R01AI054821 and R01AI093737 (to J.D.C.).

Conflict of interest

The authors declare that they have no conflict of interest

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Interdisciplinary Graduate Program in Immunology, Carver College of MedicineUniversity of IowaIowa CityUSA
  2. 2.Departments of Internal Medicine and Anatomy and Cell Biology, Carver College of MedicineUniversity of IowaIowa CityUSA

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