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Immunologic Research

, Volume 58, Issue 2–3, pp 378–386 | Cite as

Immune cells and immune-based therapy in pancreatitis

  • Jing Xue
  • Vishal Sharma
  • Aida Habtezion
IMMUNOLOGY AT STANFORD UNIVERSITY

Abstract

Alcohol and gallstones are the most common etiologic factors in acute pancreatitis (AP). Recurrent AP can lead to chronic pancreatitis (CP). Although the underlying pathophysiology of the disease is complex, immune cells are critical in the pathogenesis of pancreatitis and determining disease severity. In this review, we discuss the role of innate and adaptive immune cells in both AP and CP, potential immune-based therapeutic targets, and animal models used to understand our knowledge of the disease. The relative difficulty of obtaining human pancreatic tissue during pancreatitis makes animal models necessary. Animal models of pancreatitis have been generated to understand disease pathogenesis, test therapeutic interventions, and investigate immune responses. Although current animal models do not recapitulate all aspects of human disease, until better models can be developed available models are useful in addressing key research questions. Differences between experimental and clinical pancreatitis need consideration, and when therapies are tested, models with established disease ought to be included.

Keywords

Pancreatitis Immune cells Animal models Immune therapy 

Abbreviations

AP

Acute pancreatitis

ANS

Anti-neutrophil serum

CP

Chronic pancreatitis

IL

Interleukin

MCP

Monocyte chemotactic protein

PSCs

Pancreatic stellate cells

Th

T helper

Treg

Regulatory T cells

TLR

Toll-like receptor

TNF

Tumor necrosis factor

Notes

Acknowledgments

This work was supported by the Robert Wood Johnson Foundation grant (to A.H.), the National Institutes of Health Grant DK092421 (to A.H.), and Digestive Disease Center Grant DK56339 (to Stanford University).

Conflict of interest

The authors disclose no conflicts.

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Gastroenterology and Hepatology, Department of MedicineStanford University School of MedicineStanfordUSA

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