Immunologic Research

, Volume 58, Issue 2–3, pp 282–291

An essential role for the immune system in the mechanism of tumor regression following targeted oncogene inactivation



Tumors are genetically complex and can have a multitude of mutations. Consequently, it is surprising that the suppression of a single oncogene can result in rapid and sustained tumor regression, illustrating the concept that cancers are often “oncogene addicted.” The mechanism of oncogene addiction has been presumed to be largely cell autonomous as a consequence of the restoration of normal physiological programs that induce proliferative arrest, apoptosis, differentiation, and/or cellular senescence. Interestingly, it has recently become apparent that upon oncogene inactivation, the immune response is critical in mediating the phenotypic consequences of oncogene addiction. In particular, CD4+ T cells have been suggested to be essential to the remodeling of the tumor microenvironment, including the shutdown of host angiogenesis and the induction of cellular senescence in the tumor. However, adaptive and innate immune cells are likely involved. Thus, the effectors of the immune system are involved not only in tumor initiation, tumor progression, and immunosurveillance, but also in the mechanism of tumor regression upon targeted oncogene inactivation. Hence, oncogene inactivation may be an effective therapeutic approach because it both reverses the neoplastic state within a cancer cell and reactivates the host immune response that remodels the tumor microenvironment.


Oncogene addiction MYC Tumor recurrence Tumor microenvironment Tumor immunology 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Stephanie C. Casey
    • 1
  • Yulin Li
    • 1
  • Dean W. Felsher
    • 1
  1. 1.Division of Oncology, Departments of Medicine and PathologyStanford University School of MedicineStanfordUSA

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