Molecular studies and therapeutic targeting of Kaposi’s sarcoma herpesvirus (KSHV/HHV-8) oncogenesis
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Kaposi’s sarcoma herpesvirus or human herpesvirus-8 (KSHV/HHV-8) is the etiological agent of Kaposi’s sarcoma (KS), an AIDS-defining angioproliferative neoplasm that continues to be a major global health problem and, of primary effusion lymphoma (PEL), a rare incurable B-cell lymphoma. This review describes the research from our laboratory and its collaborators to uncover molecular mechanisms of viral oncogenesis in order to develop new pathogenesis-based therapies to the KSHV-induced AIDS malignancies KS and PEL. They include the discovery of the viral angiogenic oncogene G protein-coupled receptor (vGPCR), the development of mouse models of KSHV and oxidative stress-induced KS, the identification of the role of Rac1-induced ROS in viral oncogenesis of KS and the development of novel therapeutic approaches able to target both latent and lytic oncogenic KSHV infection.
KeywordsAIDS-associated malignancies Targeted therapies Antivirals Human herpesvirus-8 Angiogenesis Animal models of cancer
The research described in this review was funded through NIH/PHS Grants to E.A.M. AI39192, CA75918 and CA136387, by NCI/OHAM supplements to the Miami CFAR Grant 5P30AI073961, by American Cancer Society RPG-99-207-01-MBC and by the Sylvester Comprehensive Cancer Center.
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