Immunologic Research

, Volume 51, Issue 2–3, pp 205–214 | Cite as

Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model

  • Sandra Bonne-Année
  • Jessica A. Hess
  • David Abraham
Current Immunology Research at Jefferson

Abstract

Mice have been used to the study the mechanisms of protective innate and adaptive immunity to larval Strongyloides stercoralis. During primary infection, neutrophils and eosinophils are attracted by parasite components and kill the larvae by release of granule products. Eosinophils also function as antigen-presenting cells for the induction of a Th2 response. B cells produce both IgM and IgG that collaborate with neutrophils to kill worms in the adaptive immune response. Vaccine studies have identified a recombinant diagnostic antigen that induced high levels of immunity to infection with S. stercoralis in mice. These studies demonstrate that there are redundancies in the mechanisms used by the immune response to kill the parasite and that a vaccine with a single antigen may be suitable as a prophylactic vaccine to prevent human strongyloidiasis.

Keywords

Strongyloidesstercoralis Innate immunity Adaptive immunity Th2 cells B cells IgG IgM Complement Neutrophils Eosinophils Antigen-presenting cell Ss-IR Recombinant vaccine 

Notes

Acknowledgments

This research was supported in part by the Edna McConnell Foundation and by National Institutes of Health grants RO1AI47189 and 1R56AI076345. We acknowledge the contributions made by past members of the laboratory to the findings presented in this review: Richard Brigandi, Ann Marie Galioto, Frances Haberstroh, De’Broski Herbert, Larua Kerepesi, Alejandro Krolewiecki, Ofra Leon, Amy O’Connell, Udaikumar Padigel, Kevin Redding, Harris Rotman, Louis Stein, and Wiboonchai Yutanawiboonchai. We thank our past and present collaborators for their assistance with the studies discussed in this review: James Lee, James Lok, Sara Lustigman, Thomas Nolan, Thomas Nutman, and Gerhard Schad,.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sandra Bonne-Année
    • 1
  • Jessica A. Hess
    • 1
  • David Abraham
    • 1
  1. 1.Department of Microbiology and ImmunologyThomas Jefferson UniversityPhiladelphiaUSA

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