Immunologic Research

, Volume 49, Issue 1–3, pp 269–280

Immunologic aspects of monoclonal B-cell lymphocytosis


DOI: 10.1007/s12026-010-8188-4

Cite this article as:
Lanasa, M.C. & Weinberg, J.B. Immunol Res (2011) 49: 269. doi:10.1007/s12026-010-8188-4


Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic condition wherein small numbers of clonal B cells can be detected in the blood of otherwise healthy individuals. Most MBL have a surface immunophenotype nearly identical to that of chronic lymphocytic leukemia (CLL), though other phenotypes can also be identified. MBL has been shown to be a precursor state for CLL, but most MBL clones are quite small and apparently have minimal potential to progress of CLL or other B-cell lymphoproliferative disorder (B-LPD). The investigation of MBL as a precursor state for CLL will likely lead to important insights into mechanisms of disease pathogenesis. The review will cover clinical and translational aspects of MBL, with a particular emphasis on the prevalence of MBL; the relationship between MBL, CLL, and other B-LPDs; and the capacity of MBL to modulate the normal B- and T-cell compartments.


Monoclonal B lymphocytosis Chronic lymphocytic leukemia Non-Hodgkin’s lymphoma B-cell receptor B-cell development 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of MedicineDuke University Medical CenterDurhamUSA
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA
  3. 3.Department of ImmunologyDuke University Medical CenterDurhamUSA
  4. 4.Durham Veterans Affairs Medical CenterDurhamUSA

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