Immunologic aspects of monoclonal B-cell lymphocytosis
- 187 Downloads
Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic condition wherein small numbers of clonal B cells can be detected in the blood of otherwise healthy individuals. Most MBL have a surface immunophenotype nearly identical to that of chronic lymphocytic leukemia (CLL), though other phenotypes can also be identified. MBL has been shown to be a precursor state for CLL, but most MBL clones are quite small and apparently have minimal potential to progress of CLL or other B-cell lymphoproliferative disorder (B-LPD). The investigation of MBL as a precursor state for CLL will likely lead to important insights into mechanisms of disease pathogenesis. The review will cover clinical and translational aspects of MBL, with a particular emphasis on the prevalence of MBL; the relationship between MBL, CLL, and other B-LPDs; and the capacity of MBL to modulate the normal B- and T-cell compartments.
KeywordsMonoclonal B lymphocytosis Chronic lymphocytic leukemia Non-Hodgkin’s lymphoma B-cell receptor B-cell development
MC Lanasa is a fellow of the Leukemia and Lymphoma Society of America. This research was supported by the Leukemia and Lymphoma Society of America, the Bernstein Fund for Leukemia Research, the VA Research Service, and a grant from the National Institutes of Health (NCI R03 CA128030). Flow Cytometry was performed in the Duke Human Vaccine Institute Flow Cytometry Core Facility that is supported by the National Institutes of Health award AI-51445. The Genetic Epidemiology of CLL (GEC) Consortium is supported by NIH grants CA118444 and CA92153; the Intramural Research Program of the NIH, National Cancer Institute; and CLL Research Consortium. Additional support was provided by 1 UL1 RR024150 from the National Center for Research Resources (NCRR), a component of NIH and the NIH Roadmap for Medical Research, the Veterans Affairs Research Service, and CA15083 from the National Cancer Institute. The GEC member institutions are The Mayo Clinic (lead site; PI: Susan Slager, Ph.D.), Duke University, The M.D. Anderson Cancer Center, The National Cancer Institute, The University of California at San Diego, The University of Minnesota, and The University of Utah.
- 1.Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK (eds). SEER cancer statistics review, 1975–2007. 2010. Bethesda, MD: National Cancer Institute. http://seer.cancer.gov/csr/1975_2007/, based on November 2009 SEER data submission, posted to the SEER web site.
- 10.Nieto WG, et al. Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection. Cytometry B Clin Cytom. 2010;78 Suppl 1:S4–9.Google Scholar
- 11.Shim YK, et al. Prevalence of monoclonal B-cell lymphocytosis: a systematic review. Cytometry B Clin Cytom. 2010;78 Suppl 1:S10–8.Google Scholar
- 14.Goldin LR et al. Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families. Br J Haematol. 2010 (in press).Google Scholar
- 16.Crowther-Swanepoel D et al. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. Blood. 2010 (in press).Google Scholar
- 18.Shanafelt TD et al. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia. 2010;24(3):512–20.Google Scholar
- 24.Rawstron AC, et al. Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL). Cytometry B Clin Cytom. 2010;78 Suppl 1:S19–23.Google Scholar
- 25.Hauswirth A et al. Monoclonal B-cell lymphocytosis (MBL) with normal whole lymphocyte counts is associated with reduced numbers of normal circulating immature and mature B-lymphocytes. Hematologica. 95(Suppl 2):324 (abstract).Google Scholar