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Immunologic Research

, Volume 46, Issue 1–3, pp 12–22 | Cite as

Regulating functional cell fates in CD8 T cells

  • Protul A. Shrikant
  • Rajesh Rao
  • Qingsheng Li
  • Joshua Kesterson
  • Cheryl Eppolito
  • Axel Mischo
  • Pankaj Singhal
Article

Abstract

The attributes of specificity and memory enable CD8+ T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8+ T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 and/or Tcreg) and/or memory (effector or central), of CD8+ T cells most desirable for tumor immunity is not established. To determine the tumor efficacy of various effector types and/or memory CD8 T cells, it is imperative to better understand intrinsic and extrinsic factors that regulate CD8+ T cell differentiation and use this information to generate and test distinct functional cell types in tumor models. The focus of our laboratory investigations is to identify the extrinsic factors such as antigen strength, co-stimulatory molecules, cytokines, and small molecule modifiers that regulate intrinsic programs for various effector and/or memory cell fate in antigen specific CD8 T cells. The use of this information to generate immunity in murine tumor models has facilitated development of new adoptive cell transfer (ACT) as well as immunization strategies for cancer treatment.

Keywords

CD8+ T cell Cytokines Transcriptional regulators Effector and memory cell fate Adoptive cell transfer and tumor immunity 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Protul A. Shrikant
    • 1
  • Rajesh Rao
    • 1
  • Qingsheng Li
    • 1
  • Joshua Kesterson
    • 1
  • Cheryl Eppolito
    • 1
  • Axel Mischo
    • 1
  • Pankaj Singhal
    • 1
  1. 1.Department of ImmunologyRoswell Park Cancer InstituteBuffaloUSA

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