Immunologic Research

, Volume 46, Issue 1–3, pp 216–226 | Cite as

Enhancement of anti-tumor immunity by photodynamic therapy

  • Sandra O. Gollnick
  • Craig M. Brackett


Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.


PDT Neutrophil Vaccine T cell 



This work was supported by NIH Grants CA55791 and CA98156 and in part by the Roswell Park Cancer Center Support Grant CA16056.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of ImmunologyRoswell Park Cancer InstituteBuffaloUSA
  2. 2.Department of Cell Stress BiologyRoswell Park Cancer InstituteBuffaloUSA

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