Immunologic Research

, Volume 45, Issue 2–3, pp 239–250

Regulation of immunity at tissue sites of inflammation

  • Dorothy K. Sojka
  • Christopher A. Lazarski
  • Yu-Hui Huang
  • Irina Bromberg
  • Angela Hughson
  • Deborah J. Fowell
Article

Abstract

The acquisition and execution of CD4 effector function are tightly regulated and spatially compartmentalized. In the lymph node (LN), naïve CD4+ T cells acquire specialized functions by means of expression of distinct cytokines and acquire distinct homing properties. Therefore, both the function and subsequent localization of effector cells appears to be predetermined during differentiation in the LN. Our studies with the protozoa Leishmania major suggest that this centrally (LN) generated effector repertoire can be further edited at the infected tissue site. Cytokine production in the inflamed tissue can be modulated at a number of levels including chemokine-driven differential recruitment of effector cells, the provision of signals for effector cell function and suppression by regulatory T cells (Tregs). The concept that tissue resident pathogens may subvert the centrally generated cytokine repertoire has important therapeutic implications. Novel therapies that focus on manipulating the local infection site to encourage appropriate recruitment or activation of effectors may be particularly beneficial.

Keywords

CD4 T cell Cytokine Chemokine Inflamed tissue Recruitment Regulatory T cell Leishmania major 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Dorothy K. Sojka
    • 1
  • Christopher A. Lazarski
    • 1
  • Yu-Hui Huang
    • 1
  • Irina Bromberg
    • 1
  • Angela Hughson
    • 1
  • Deborah J. Fowell
    • 1
  1. 1.David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and ImmunologyUniversity of RochesterRochesterUSA

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