IRF8 regulates myeloid and B lymphoid lineage diversification
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Interferon regulatory factor 8 (IRF8) is a member of the IRF family of transcription factors whose members play critical roles in interferon (IFN) signaling pathways governing the establishment of innate immune responses by myeloid and dendritic cells. IRF8 is also expressed in lymphoid cells and recent studies have documented its involvement in B cell lineage specification, immunoglobulin light chain gene rearrangement, the distribution of mature B cells into the marginal zone and follicular B cell compartment, and the transcriptional regulation of critical elements of the germinal center reaction. Here we review the contributions of IRF8 to B cell development from hematopoietic stem cells in the bone marrow and its place in the hierarchical regulatory network governing specification and commitment to the B cell fate.
KeywordsHematopoietic stem cell Common lymphoid progenitor IRF8 PU.1 EBF PAX5 E2A Pre-pro-B Lineage B cell
The authors thank Drs. Keiko Ozato and Prafullakumar Tailor, NICHD, for providing BXH2 mice, and members of LIP and the Ozato laboratory for many helpful discussions. This study was supported by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases.
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