Immunologic Research

, Volume 42, Issue 1–3, pp 132–144

Regulation of T cell integrin function by adapter proteins

Article

DOI: 10.1007/s12026-008-8047-8

Cite this article as:
Baker, R.G. & Koretzky, G.A. Immunol Res (2008) 42: 132. doi:10.1007/s12026-008-8047-8

Abstract

Integrins are cell surface heterodimers that bind adhesion molecules expressed on other cells or in the extracellular matrix. Integrin-mediated interactions are critical for T cell development in the thymus, migration of T cells in the periphery, and induction of T cell effector functions. In resting T cells, integrins are maintained in a low affinity state. Engagement of the T cell receptor or chemokine receptors increases integrin affinity, enabling integrins to bind their ligands and initiate a signaling cascade resulting in altered cell morphology and motility. Our laboratory is interested how adapter proteins, mediators of intracellular signal transduction, regulate both signals from the T cell receptor to integrins (inside-out signaling) and (outside-in) signals from integrins into the cell.

Keywords

T lymphocyte Signaling Integrins Adapters 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Leonard and Madlyn Abramson Family Cancer Research InstituteUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  3. 3.Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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