Immunologic Research

, Volume 39, Issue 1–3, pp 240–248

Characterization of splenic CD21hi T2 B cells


DOI: 10.1007/s12026-007-0072-5

Cite this article as:
Verma, S. & Waldschmidt, T.J. Immunol Res (2007) 39: 240. doi:10.1007/s12026-007-0072-5


B cell development is a highly regulated process that initiates in the bone marrow (BM) of adult mice. After reaching the IgM+ immature stage in the BM, these B cells migrate to the spleen to complete maturation and incorporation into the long-lived peripheral lymphocyte pool. Studies have identified these splenic immature B cells, and have further attempted to delineate the sequence whereby they transition into mature B cells. As such, these immature splenic populations are termed transitional B cells and have been the focus of intense study. The review summarizes the phenotype and currently known functions of the four putative transitional B cell subsets identified to date. Although most appear to represent short-lived transitional B cells, the CD21hi T2 B cell population exhibits a number of qualities that question its label as a transitional B cell subset.


B lymphocytes Transitional B cells CD21hi T2 B cell development 

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  1. 1.Interdisciplinary Graduate Program in ImmunologyUniversity of IowaIowa CityUSA
  2. 2.Department of Pathology, Carver College of MedicineUniversity of IowaIowa CityUSA
  3. 3.1038 Medical LaboratoriesUniversity of IowaIowa CityUSA

Personalised recommendations