Immunologic Research

, Volume 40, Issue 1, pp 35–48 | Cite as

Understanding the multiple functions of Gr-1+ cell subpopulations during microbial infection

  • Charlotte E. Egan
  • Woraporn Sukhumavasi
  • Allison L. Bierly
  • Eric Y. Denkers
Article

Abstract

The murine cell surface determinant Gr-1 is expressed at high level on neutrophils. Depletion of polymorphonuclear leukocytes with anti-Gr-1+ monoclonal antibody results in increased susceptibility and dysregulated immunity to many microbial pathogens, a finding widely interpreted to indicate the importance of neutrophils during infection. Yet, in recent years it has become clear that additional cell types express the Gr-1 determinant, including dendritic cell and monocyte subpopulations. In this review, we evaluate current knowledge on the functional aspects of Gr-1+ cell populations. We focus on infection with the opportunistic protozoan Toxoplasma gondii, a case where host survival depends on an intact Gr-1+ cell population.

Keywords

Neutrophil Dendritic cell Monocyte Innate immunity Infection 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Charlotte E. Egan
    • 1
  • Woraporn Sukhumavasi
    • 1
  • Allison L. Bierly
    • 1
  • Eric Y. Denkers
    • 1
  1. 1.Department of Microbiology and Immunology, College of Veterinary MedicineCornell UniversityIthacaUSA

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