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Forensic Science, Medicine and Pathology

, Volume 14, Issue 3, pp 327–331 | Cite as

Lymphoma in autopsy cases

  • Ahmad Alkhasawneh
  • Aysha Mubeen
  • Arun Gopinath
Original Article

Abstract

Lymphoproliferative disorders cause significant morbidity and mortality, either related to the disease itself or therapy complications. Some cases of lymphoma may have vague clinical presentation, especially in the absence of lymphadenopathy, and a clinical work up may not be conclusive. Our study focuses on autopsy cases of lymphoma patients, emphasizing clinically unsuspected cases. Autopsy records from the last 20 years at our institution were searched, and the clinical parameters were recorded. Fifteen cases of lymphoma were identified, and 5 cases were diagnosed at the time of autopsy. Most B-cell lymphoma cases were mainly nodal disease, while T-cell lymphoma cases had widespread extra-nodal disease. Most deaths in B-cell lymphoma are due to infection/therapy induced immunosuppression, whereas T-cell lymphoma deaths are due to organ infiltration by lymphoma. Postmortem examination may reveal clinically unsuspected lymphoma, especially in rapidly deteriorating patients with vague presentation such as skin rash, bowel obstruction/bleeding or pacemaker malfunction.

Keywords

Autopsy Lymphoma Lymphadenopathy Immunosuppression 

Notes

Author contributions

Aysha Mubeen: writing abstract and data collection. Arun Gopinath: writing abstract and data collection.

Compliance with ethical standards

Financial support

No supports was received by all authors.

Conflict of interest

No conflict of interest for all authors.

Ethical approval

IRB201601803 UF Health Jacksonville.

Informed consent

Not needed/ retrospective study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ahmad Alkhasawneh
    • 1
  • Aysha Mubeen
    • 1
  • Arun Gopinath
    • 1
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Florida College of Medicine – JacksonvilleJacksonvilleUSA

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