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Forensic Science, Medicine and Pathology

, Volume 14, Issue 4, pp 564–567 | Cite as

Testicular morphology in hypogonadotropic hypogonadism after the abuse of anabolic steroids

  • Armin AlibegovićEmail author
Images in Forensics

Abstract

Hypogonadism in men results from the failure of the testes to produce physiological levels of testosterone and a normal number of spermatozoa due to a disruption of the hypothalamic-pituitary-testicular axis. An example of secondary hypogonadism as a result of anabolic steroid abuse is presented with the case report of a man who committed suicide after a history of aggressive behavior and physical abuse of his wife. The autopsy revealed shrunken testicles, with more than 30% of parenchymatous sclerosis, absent spermatogenesis, and very few Leydig cells detected only by immunohistochemistry. A low-specific immunochemical analysis revealed a very high level of total testosterone (serum 109.8 nmol/L; urine 81.2 nmol/L). A more accurate analysis confirmed an overdose of synthetic anabolic steroids. Doctors in different medical areas should be alerted to chronic abusers of synthetic anabolic steroids among the growing number of recreational athletes.

Keywords

Hypogonadotropic hypogonadism Anabolic steroids Testosterone Leydig cells Erectile dysfunction Fertility 

Notes

Compliance with ethical standards

Ethical approval

No ethical approval was required.

Conflict of interest

The author declares that he has no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Forensic Medicine, Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia

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