Forensic Science, Medicine, and Pathology

, Volume 11, Issue 4, pp 577–583 | Cite as

Takotsubo cardiomyopathy associated with rupture of the left ventricular apex: assessment of histopathological features of a fatal case and literature review

  • Francesca Indorato
  • Yoshihiro J. Akashi
  • Carlo Rossitto
  • Cataldo Raffino
  • Giovanni Bartoloni
Case Report

Abstract

Takotsubo cardiomyopathy, also known as “broken heart syndrome,” is a cardiac entity characterized by transient left ventricular dysfunction without obstructive atherosclerotic coronary artery disease. An episode of emotional stress is believed to act as a trigger in the development of this syndrome, which typically occurs in female patients. We report a fatal case of a previously healthy 70-year-old woman who suffered an out-of-hospital cardiac arrest and cardiac rupture during emotional distress, due to Takotsubo cardiomyopathy. Ventricular rupture with Takotsubo cardiomyopathy is rare, but our case emphasizes the importance of dealing with this serious and potentially life-threatening disease. Takotsubo cardiomyopathy should be considered as a differential diagnosis in cases of early-developing heart failure, and clinicians should subsequently use adequate diagnostic and therapeutic options.

Keywords

Takotsubo cardiomyopathy Ventricular rupture Stress cardiomyopathy Emotional stress 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Francesca Indorato
    • 1
  • Yoshihiro J. Akashi
    • 2
  • Carlo Rossitto
    • 3
  • Cataldo Raffino
    • 3
  • Giovanni Bartoloni
    • 1
  1. 1.Department “GF Ingrassia”, Section of Legal MedicineUniversity of CataniaCataniaItaly
  2. 2.Division of Cardiology, Department of Internal MedicineSt. Marianna University School of MedicineKawasakiJapan
  3. 3.Diagnostic PathologyGaribaldi Nesima HospitalCataniaItaly

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